ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2008
Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Childhood obesity from the genes to the epigenome.Frontiers in endocrinology · 2024Review
- PACAP and VIP Neuropeptides' and Receptors' Effects on Appetite, Satiety and Metabolism.Biology · 2023Review
- Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.Genes, brain, and behavior · 2020Article
- In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice.PloS one · 2020Article
- The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder.Frontiers in cellular neuroscience · 2020Review
- Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cells.Scientific reports · 2019Article
- Altered social behavior in mice carrying a cortical Foxp2 deletion.Human molecular genetics · 2019Article
- Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP).Journal of molecular neuroscience : MN · 2015Article
- VPAC receptor signaling modulates grouping behavior and social responses to contextual novelty in a gregarious finch: a role for a putative prefrontal cortex homologue.Hormones and behavior · 2013Article
- Article
- A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.Schizophrenia bulletin · 2010Article
- Mice deficient in both pituitary adenylyl cyclase-activating polypeptide and vasoactive intestinal peptide survive, but display growth retardation and sex-dependent early death.Journal of molecular neuroscience : MN · 2008Article
- Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice.Experimental neurology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Pharmacological studies indicate that vasoactive intestinal peptide (VIP) may be necessary for normal embryonic development in the mouse. For example, VIP antagonist treatment before embryonic day 11 resulted in developmental delays, growth restriction, modified adult brain chemistry and reduced social behavior. Here, developmental milestones, growth, and social behaviors of neonates of VIP-deficient mothers (VIP +/-) mated to VIP +/- males were compared with the offspring of wild type mothers (VIP +/+) mated to VIP +/+ and +/- males, to assess the contributions of both maternal and offspring VIP genotype. Regardless of their own genotype, all offsprings of VIP-deficient mothers exhibited developmental delays. No delays were seen in the offspring of wild type mothers, regardless of their own genotype. Body weights were significantly reduced in offspring of VIP-deficient mothers, with VIP null (-/-) the most affected. Regardless of genotype, all offspring of VIP-deficient mothers expressed reduced maternal affiliation compared with wild type offspring of wild type mothers; +/- offspring of wild type mothers did not differ in maternal affiliation from their wild type littermates. Play behavior was significantly reduced in all offsprings of VIP-deficient mothers. Maternal behavior did not differ between wild type and VIP-deficient mothers, and cross-fostering of litters did not change offspring development, indicating that offspring deficits were induced prenatally. This study illustrated that the VIP status of a pregnant mouse had a greater influence on the growth, development and behavior of her offspring than the VIP genotype of the offspring themselves. Deficiencies were apparent in +/+, +/- and -/- offspring born to VIP-deficient mothers; no deficiencies were apparent in +/- offspring born to normal mothers. These results underscore the significant contribution of the uterine environment to normal development and indicate a potential usefulness of the VIP knockout mouse in furthering the understanding of neurodevelopmental disorders with social behavior deficits such as autism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.