ArticleThe Journal of urology2008
Stress urinary incontinence: relative importance of urethral support and urethral closure pressure.
Article in The Journal of urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 111 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Case Control Study to Investigate the Use of Urethral Pressure Profile Measurement in Children
Valsalva Urethral Profile (VUP) : a New Measure to Assess Stress Urinary Incontinence in Women
Do Intravaginal Devices Reduce or Eliminate Exercise Induced Urinary Incontinence in Female Runners?
Who cites it
111 citing papers in PubMed, 6 syntheses or guidelines pooled it, 261 citations in OpenAlex.
- The Impact of Non-Radical Hysterectomy on Urinary Functions: Evaluation of Symptoms-A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Effect of vaginal energy-based treatment on female stress urinary incontinence: a systematic review and meta-analysis of randomized controlled trials.World journal of urology · 2023Pooled it
- The pathophysiology of stress urinary incontinence: a systematic review and meta-analysis.International urogynecology journal · 2021Pooled it
- Pooled it
- Pelvic floor muscle activity during impact activities in continent and incontinent women: a systematic review.International urogynecology journal · 2018Pooled it
- Slings in surgery of genuine stress incontinence.World journal of urology · 2012Pooled it
- Low-Intensity Extracorporeal Shock Wave Therapy Restores Passive Urethral Closure Mechanism in Vaginal Distension Rat Model.International urogynecology journal · 2026Article
- Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.The Journal of physiology · 2026Review
- Electrotherapy Plus Photobiostimulation for the Treatment of Mild Pelvic Organ Prolapse and Stress Urinary Incontinence.Journal of clinical medicine · 2026Article
- Urinary incontinence during pregnancy and in the postpartum period.Nature reviews. Urology · 2026Review
- Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.Journal of muscle research and cell motility · 2025Review
- Clinical Course and Conservative Strategy for Persistent De Novo Stress Urinary Incontinence After Pelvic Organ Prolapse Repair with Transvaginal Mesh.Biomedicines · 2025Article
- Are Urethral Pressure Profile Measurements Effective in Diagnosing Urodynamic Stress Incontinence in Women Presenting with Stress or Mixed Urinary Incontinence? Results from a Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- A New Automated Ultrasound Quantification of Urethral Mobility for Stress Urinary Incontinence: A Feasibility Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Expanded Physiological Testing of the Lower Urinary Tract in Asymptomatic Women and Those With Urgency Urinary Incontinence: Findings From the LURN-Organ Study.Neurourology and urodynamics · 2025Observational
- Exploring the connection between the hip and pelvic floor in women with exercise-induced urinary incontinence: integrating clinical hypotheses with current evidence.Journal of pelvic, obstetric and gynaecological physiotherapy · 2025Article
- Article
- Correlation analysis of selected anatomical and functional parameters of the urethra, assessed through ultrasound and urodynamic examinations.Journal of ultrasonography · 2024Article
- Assessment of perineal body properties in women with stress urinary incontinence using Transperineal shear wave elastography.Scientific reports · 2024Article
- MR defecography in assessing stress urinary incontinence with or without symptomatic pelvic organ prolapse.World journal of urology · 2024Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTreatment strategies for stress incontinence are based on the concept that urethral mobility is the predominant causal factor with sphincter function a secondary contributor. To our knowledge the relative importance of these 2 factors has not been assessed in properly controlled studies. MATERIALS AND
methodsThe Research on Stress Incontinence Etiology project is a case-control study that compared 103 women with stress incontinence and 108 asymptomatic controls in groups matched for age, race, parity and hysterectomy. Urethral closure pressure, urethral and pelvic organ support, levator ani muscle function and intravesical pressure were measured and analyzed using logistic regression and multivariable modeling.
resultsMean +/- SD maximal urethral closure pressure was 42% lower in cases (40.8 +/- 17.1 vs 70.2 +/- 22.4 cm H(2)O, d = 1.47). Lesser effect sizes were seen for support parameters, including resting urethral axis and urethrovaginal support (d = 0.41 and 0.50, respectively). Other pelvic floor parameters, including genital hiatus size and urethral axis during muscle contraction (d = 0.60 and 0.58, respectively), differed but levator strength and levator defect status did not. Maximum cough pressure, which is an assessment of stress on the continence mechanism, was also different (d = 0.43). After adjusting for body mass index the maximal urethral closure pressure alone correctly classified 50% of cases. Adding the best predictors for urethrovaginal support and cough strength to the model added 11% of predictive ability.
conclusionsThe finding that maximal urethral closure pressure and not urethral support is the factor most strongly associated with stress incontinence implies that improving urethral function may have therapeutic promise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.