ArticleThe Journal of allergy and clinical immunology2008
Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses.
Article in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- BRD4-PRC2 represses transcription of T-helper 2-specific negative regulators during T-cell differentiation.The EMBO journal · 2023Article
- The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition.Frontiers in genetics · 2019Article
- miR-34a-mediated regulation of XIST in female cells under inflammation.Journal of pain research · 2018Article
- YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity.Nature communications · 2016Article
- Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Roles Each of Snail, Yin Yang 1 and RKIP in the Regulation of Tumor Cells Chemo-immuno-resistance to Apoptosis.Forum on immunopathological diseases and therapeutics · 2013Article
- CC-chemokine ligand 18 induces epithelial to mesenchymal transition in lung cancer A549 cells and elevates the invasive potential.PloS one · 2013Article
- Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Yin yang 1 is a novel regulator of pulmonary fibrosis.American journal of respiratory and critical care medicine · 2011Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of several T-cell cytokine genes, but the expression and contribution of this factor to cytokine gene expression and T-cell activation in vivo is not clear.
objectiveWe sought to better define the role of YY-1 in T-cell gene regulation and allergic immune responses.
methodsWe studied cytokine gene expression in T lymphocytes isolated from wild-type mice and heterozygous littermates bearing 1 targeted yy-1 allele (yy-1(+/-) mice). T cells were stimulated with anti-T-cell receptor (anti-TCR) plus CD28 antibodies or with peptide antigen plus antigen-presenting cells by using newly generated yy-1(+/-) TCR transgenic mice. We also studied ovalbumin-driven allergic immune responses in a mouse model of asthma and YY-1 expression in lung tissue from human asthmatic subjects.
resultsCD4(+) T cells from yy-1(+/-) mice secreted significantly less IL-4 and IFN-gamma compared with wild-type littermates after TCR-dependent activation, whereas IL-2 production was not significantly affected. Both airway inflammation and recall splenocyte IL-4 production were inhibited in yy-1(+/-) mice, as was antigen-driven T-cell proliferation. YY-1 expression was higher in airway biopsy specimens from asthmatic compared with control subjects.
conclusionThese data indicate that YY-1 regulates T-cell cytokine gene expression and allergic immune responses in a gene dose-dependent manner.
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