ArticleAmerican journal of human genetics2008
Linkage disequilibrium between STRPs and SNPs across the human genome.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.Brain : a journal of neurology · 2023Pooled it
- Toward minimal SNP sets for record-matching with CODIS STR profiles.European journal of human genetics : EJHG · 2026Article
- Exploring imputation performance of phenotype-associated SNPs for forensic prediction models.Scientific reports · 2026Article
- The contribution of short tandem repeats to splicing variation in the human cortex.bioRxiv : the preprint server for biology · 2026Article
- Identifying individuals with rare disease variants by inferring shared ancestral haplotypes from SNP array data.NAR genomics and bioinformatics · 2025Article
- Characterization and visualization of tandem repeats at genome scale.Nature biotechnology · 2024Article
- Microsatellites used in forensics are in regions enriched for trait-associated variants.iScience · 2023Article
- Microsatellites used in forensics are located in regions unusually rich in trait-associated variants.bioRxiv : the preprint server for biology · 2023Article
- Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.Molecular psychiatry · 2022Review
- Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.Scientific reports · 2021Article
- Translational genomics and beyond in bipolar disorder.Molecular psychiatry · 2021Review
- Mathematical Properties of Linkage Disequilibrium Statistics Defined by Normalization of the Coefficient D = pAB - pApB.Human heredity · 2019Article
- Modeling copy number variation in the genomic prediction of maize hybrids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- A reference haplotype panel for genome-wide imputation of short tandem repeats.Nature communications · 2018Article
- Massive variation of short tandem repeats with functional consequences across strains ofGenome research · 2018Article
- Linkage disequilibrium matches forensic genetic records to disjoint genomic marker sets.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Linking short tandem repeat polymorphisms with cytosine modifications in human lymphoblastoid cell lines.Human genetics · 2016Article
- Abundant contribution of short tandem repeats to gene expression variation in humans.Nature genetics · 2016Article
- The landscape of human STR variation.Genome research · 2014Article
- Genome-wide association mapping of blood cell traits in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Patterns of linkage disequilibrium (LD) reveal the action of evolutionary processes and provide crucial information for association mapping of disease genes. Although recent studies have described the landscape of LD among single nucleotide polymorphisms (SNPs) from across the human genome, associations involving other classes of molecular variation remain poorly understood. In addition to recombination and population history, mutation rate and process are expected to shape LD. To test this idea, we measured associations between short-tandem-repeat polymorphisms (STRPs), which can mutate rapidly and recurrently, and SNPs in 721 regions across the human genome. We directly compared STRP-SNP LD with SNP-SNP LD from the same genomic regions in the human HapMap populations. The intensity of STRP-SNP LD, measured by the average of D', was reduced, consistent with the action of recurrent mutation. Nevertheless, a higher fraction of STRP-SNP pairs than SNP-SNP pairs showed significant LD, on both short (up to 50 kb) and long (cM) scales. These results reveal the substantial effects of mutational processes on LD at STRPs and provide important measures of the potential of STRPs for association mapping of disease genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.