ArticleAmerican journal of human genetics2008
Consistently replicating locus linked to migraine on 10q22-q23.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- [Gender differences in children and adolescents with migraine].Schmerz (Berlin, Germany) · 2026Review
- The interictal transcriptomic map of migraine without aura.The journal of headache and pain · 2025Article
- The Dawn and Advancement of the Knowledge of the Genetics of Migraine.Journal of clinical medicine · 2024Review
- An emerging spectrum of variants and clinical features inChannels (Austin, Tex.) · 2021Review
- Classifying migraine subtypes and their characteristics by latent class analysis using data of a nation-wide population-based study.Scientific reports · 2021Article
- Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCirculation. Genomic and precision medicine · 2021Article
- Family studies to find rare high risk variants in migraine.The journal of headache and pain · 2017Review
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Journal of affective disorders · 2015Article
- Future possibilities in migraine genetics.The journal of headache and pain · 2012Review
- Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.Gene · 2012Article
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- Genetics of migraine in the age of genome-wide association studies.The journal of headache and pain · 2012Review
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- Article
- A visual migraine aura locus maps to 9q21-q22.Neurology · 2010Article
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura.Cephalalgia : an international journal of headache · 2009Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 4 countries.
Funding
Abstract
Here, we present the results of two genome-wide scans in two diverse populations in which a consistent use of recently introduced migraine-phenotyping methods detects and replicates a locus on 10q22-q23, with an additional independent replication. No genetic variants have been convincingly established in migraine, and although several loci have been reported, none of them has been consistently replicated. We employed the three known migraine-phenotyping methods (clinical end diagnosis, latent-class analysis, and trait-component analysis) with robust multiple testing correction in a large sample set of 1675 individuals from 210 migraine families from Finland and Australia. Genome-wide multipoint linkage analysis that used the Kong and Cox exponential model in Finns detected a locus on 10q22-q23 with highly significant evidence of linkage (LOD 7.68 at 103 cM in female-specific analysis). The Australian sample showed a LOD score of 3.50 at the same locus (100 cM), as did the independent Finnish replication study (LOD score 2.41, at 102 cM). In addition, four previously reported loci on 8q21, 14q21, 18q12, and Xp21 were also replicated. A shared-segment analysis of 10q22-q23 linked Finnish families identified a 1.6-9.5 cM segment, centered on 101 cM, which shows in-family homology in 95% of affected Finns. This region was further studied with 1323 SNPs. Although no significant association was observed, four regions warranting follow-up studies were identified. These results support the use of symptomology-based phenotyping in migraine and suggest that the 10q22-q23 locus probably contains one or more migraine susceptibility variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.