ArticleCell2008
Rethinking pseudokinases.
Article in Cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Conservation of land plant-specific receptor-like cytoplasmic kinase subfamily XI possessing a unique kinase insert domain.Frontiers in plant science · 2023Article
- Cask methylation involved in the injury of insulin secretion function caused by interleukin1-β.Journal of cellular and molecular medicine · 2020Article
- High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.Journal of the American Chemical Society · 2020Article
- Pseudoscaffolds and anchoring proteins: the difference is in the details.Biochemical Society transactions · 2017Review
- Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow.Journal of molecular biology · 2017Review
- Ten things you should know about protein kinases: IUPHAR Review 14.British journal of pharmacology · 2015Review
- The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.The Biochemical journal · 2015Article
- Kinases and pseudokinases: lessons from RAF.Molecular and cellular biology · 2014Review
- Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B.Molecular and cellular biology · 2013Article
- Pseudokinases from a structural perspective.Biochemical Society transactions · 2013Review
- An evolutionary perspective on the kinome of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Diversity, classification and function of the plant protein kinase superfamily.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.Journal of cellular physiology · 2012Article
- A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life.PloS one · 2012Article
- Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.International journal for parasitology · 2012Review
- Novel structural components of the ventral disc and lateral crest in Giardia intestinalis.PLoS neglected tropical diseases · 2011Article
- Pseudokinases-remnants of evolution or key allosteric regulators?Current opinion in structural biology · 2010Review
- Article
- Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses.Cell host & microbe · 2010Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pseudokinases lack conservation of one or more of the catalytic residues in the kinase core and as a consequence are typically thought to be catalytically inactive. New work by Mukherjee et al. (2008) challenges this assumption. They show that the pseudokinase domain of CASK (Ca2+/calmodulin activated serine-threonine kinase) adopts an active conformation and displays catalytic activity in vivo.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.