ArticleCritical care (London, England)2008
The pursuit of a high central venous oxygen saturation in sepsis: growing concerns.
Article in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Bundled care for septic shock: an analysis of clinical trials.Critical care medicine · 2010Pooled it
- Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2012Trial
- Gastric tonometry versus cardiac index as resuscitation goals in septic shock: a multicenter, randomized, controlled trial.Critical care (London, England) · 2009Trial
- The Value of Combining Carbon Dioxide Gap and Oxygen-Derived Variables with Lactate Clearance in Predicting Mortality after Resuscitation of Septic Shock Patients.Critical care research and practice · 2021Article
- Circulatory effects of dexmedetomidine in early sepsis: a randomised controlled experimental study.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Combination of OJournal of thoracic disease · 2019Review
- Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK-a randomized controlled trial.Annals of intensive care · 2018Article
- Endorsing performance measures is a matter of trust.BMJ (Clinical research ed.) · 2018Article
- The venous-arterial partial pressure of carbon dioxide as a new monitoring of circulatory disorder: no so simple.Journal of clinical monitoring and computing · 2016Article
- Understanding the venous-arterial COIntensive care medicine · 2016Review
- Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.Critical care (London, England) · 2016Review
- Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?Intensive care medicine · 2016Article
- Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock.Intensive care medicine · 2015Article
- Earliest Bedside Assessment of Hemodynamic Parameters and Cardiac Biomarkers: Their Role as Predictors of Adverse Outcome in Patients with Septic Shock.International journal of medical sciences · 2015Article
- Central venous oxygenation: when physiology explains apparent discrepancies.Critical care (London, England) · 2014Review
- Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study.Critical care (London, England) · 2014Observational
- Observational
- The Surviving Sepsis Campaign's Revised Sepsis Bundles.Current infectious disease reports · 2013Article
- Can calculated central venous saturation be used as a reliable tool to guide therapy in patients with shock?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2013Article
- Surviving sepsis: going beyond the guidelines.Annals of intensive care · 2011Article
Corrections and comments
- Comment on
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Critical Care, Dutch investigators report that, in a cohort of patients with sepsis/septic shock admitted to three different intensive care units (ICUs), low central venous oxygen saturation (ScvO2) was uncommon at the time of ICU admission, and hospital mortality was <30%. Their findings, taken together with those of recent reports from Australia and New Zealand (ANZ), raise serious concerns about the utility of early goal directed therapy (EGDT) outside the context of the original trial. Despite inclusion of EGDT into the Surviving Sepsis Guidelines, in response to growing uncertainty, ANZ and US investigators will soon begin randomization of patients into two large multicentre trials comparing EGDT to standard therapy. Until such studies are completed, basing international treatment guidelines on a single centre study performed in what may turn out to be a highly atypical environment would seem premature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.