ReviewAddiction (Abingdon, England)2008
Critical issues in the treatment of hepatitis C virus infection in methadone maintenance patients.
Review in Addiction (Abingdon, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Trial
- Hepatitis C Virus Direct-Acting Antiviral Treatment Adherence Patterns and Sustained Viral Response Among People Who Inject Drugs Treated in Opioid Agonist Therapy Programs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Intensive Models of Hepatitis C Care for People Who Inject Drugs Receiving Opioid Agonist Therapy: A Randomized Controlled Trial.Annals of internal medicine · 2019Trial
- Risk Factors Associated with HCV Among Opioid-Dependent Patients in a Multisite Study.Journal of community health · 2015Trial
- Cost-effectiveness of rapid hepatitis C virus (HCV) testing and simultaneous rapid HCV and HIV testing in substance abuse treatment programs.Addiction (Abingdon, England) · 2015Trial
- Pharmacokinetic interaction between telaprevir and methadone.Antimicrobial agents and chemotherapy · 2013Trial
- Psychiatric and substance use disorders among methadone maintenance patients with chronic hepatitis C infection: effects on eligibility for hepatitis C treatment.The American journal on addictionsTrial
- Health service utilization, substance use treatment response, and death in patients with opioid use disorder and comorbid hepatitis C findings from prospective cohort study with administrative database linkage.Journal of substance use and addiction treatment · 2024Article
- Opportunities and ChallengesAJPM focus · 2023Article
- High HCV cure rates among people who inject drugs and have suboptimal adherence: A patient-centered approach to HCV models of care.The International journal on drug policy · 2021Article
- High retention in an opioid agonist therapy project in Durban, South Africa: the role of best practice and social cohesion.Harm reduction journal · 2020Article
- Alcohol use in opioid agonist treatment.Addiction science & clinical practice · 2016Review
- Hepatitis C Virus Testing and Treatment Among Persons Receiving Buprenorphine in an Office-Based Program for Opioid Use Disorders.Journal of substance abuse treatment · 2016Article
- Intolerance of sublingual buprenorphine-naloxone during induction in a patient with end-stage liver disease: A case report.The mental health clinician · 2016Article
- Hepatitis C virus infection and pain sensitivity in patients on methadone or buprenorphine maintenance therapy for opioid use disorders.Drug and alcohol dependence · 2015Article
- A window of opportunity: maximizing the effectiveness of new HCV regimens in the United States with the expansion of the Affordable Care Act.American journal of public health · 2015Article
- Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.Antimicrobial agents and chemotherapy · 2015Article
- Profiting and providing less care: comprehensive services at for-profit, nonprofit, and public opioid treatment programs in the United States.Medical care · 2014Article
- The impact of lifetime drug use on hepatitis C treatment outcomes in insured members of an integrated health care plan.Drug and alcohol dependence · 2014Article
- Protease inhibitors for hepatitis C: economic implications.PharmacoEconomics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
aimsHepatitis C virus (HCV) infection is a common chronic complication of injection drug use. Methadone maintenance programs contain large numbers of patients infected with HCV. This paper reviews HCV infection with emphasis on the medical care of HCV-infected, or HCV and human immunodeficiency virus co-infected, patients on methadone or buprenorphine maintenance.
methodsLiterature searches using PubMed, PsycINFO and SocINDEX were used to identify papers from 1990-present on antiviral therapy for HCV in methadone maintenance patients and on liver transplantation in methadone maintenance patients.
resultsInjection drug use is the most significant risk factor for HCV infection in most western countries. The prevalence of HCV antibody is high in injection drug users (53-96%) and in patients enrolled in methadone maintenance programs (67-96%). Studies of antiviral therapy for HCV in methadone maintenance patients show rates of sustained virological response (SVR), defined as negative HCV-RNA 24 weeks after the end of treatment, of 28-94%. In studies with contrast groups, no significant differences in SVR between methadone and contrast groups were found. Excellent completion rates of antiviral therapy (72-100%) were found in five of six studies. There are many barriers to methadone maintenance patients' receiving antiviral therapy, and research on overcoming barriers is discussed. Liver transplantation has been successful in methadone maintenance patients but has not been utilized widely.
conclusionHigh quality medical care for all aspects of HCV infection can be provided to methadone maintenance patients. The literature supports the effectiveness of such services, but the reality is that most patients do not receive them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.