ArticleCancer science2008
Overexpression of calcineurin B subunit (CnB) enhances the oncogenic potential of HEK293 cells.
Article in Cancer science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis.International journal of molecular sciences · 2020Review
- Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia.PloS one · 2020Article
- Article
- Optimizing conditions for calcium phosphate mediated transient transfection.Saudi journal of biological sciences · 2017Article
- Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.Molecular microbiology · 2011Article
- Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative Oncogene.International journal of biomedical science : IJBS · 2011Article
- Immortalized cells and one oncogene in malignant transformation: old insights on new explanation.BMC cell biology · 2011Article
- Calcineurin promotes proliferation, migration, and invasion of small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010Article
- Cytomorphology and Gene Expression Signatures of Anchorage-independent Aggregations of Oral Cancer Cells.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcineurin (CaN) is a Ca(2+)/calmodulin (CaM)-stimulated protein phosphatase. It is a heterodimeric enzyme consisting of a catalytic A subunit (CnA) and a Ca(2+)-binding regulatory B subunit (CnB). CaN's key role in vivo is well known, while the function of CnB keeps unclear except that it acts as a regulator of CaN. The present paper shows that CnB overexpression promotes proliferation of human embryonic kidney HEK293 cells by comparing with vector control cells in the complete or serum reduced medium. Furthermore, stable CnB transfectants showed dramatically improved growth in soft agar. And the migration ability of CnB overexpressors also was enhanced remarkably. But in the progress of transformation, the activity of CaN remained unchanged between CnB overexpressors and controls. Therefore, CnB, rather than CaN, is involved in the proliferation promotion of HEK293 cells. Subsequently, 11 proteins with different expression levels between CnB transfectants and controls were identified using two-dimensional gel electrophoresis and electrospray ionization time-of-fight mass spectrometry. Therein, the expression of heat shock protein 27 (HSP27) and protein DJ-1 increased along with CnB overexpression. The important role of CnB in cell neoplastic transformation was found and the possible mechanism was analyzed.
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