ArticleClinical and experimental immunology2008
Study of Toll-like receptor gene loci in sarcoidosis.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells.Respiratory research · 2024Article
- Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model.Scientific reports · 2020Article
- Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis.The European respiratory journal · 2019Article
- Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2.American journal of respiratory cell and molecular biology · 2017Article
- Fungal cell wall agents and bacterial lipopolysaccharide in organic dust as possible risk factors for pulmonary sarcoidosis.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?Wiener medizinische Wochenschrift (1946) · 2014Review
- [Genetic risk profile of sarcoidosis].Der Internist · 2014Article
- Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study.Molecular biology reports · 2013Article
- Toll like receptors in diseases of the lung.International immunopharmacology · 2011Review
- The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniques.Inflammopharmacology · 2011Review
- Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.Molecular vision · 2011Article
- Investigation of Toll-like receptors in the pathogenesis of fibrotic and granulomatous disorders: a bronchoalveolar lavage study.Fibrogenesis & tissue repair · 2010Article
- Toll-like receptor (TLR)-9 genetics and function in sarcoidosis.Clinical and experimental immunology · 2010Article
- Dendritic cells in the pathogenesis of sarcoidosis.American journal of respiratory cell and molecular biology · 2010Review
- Higher monocyte expression of TLR2 and TLR4, and enhanced pro-inflammatory synergy of TLR2 with NOD2 stimulation in sarcoidosis.Journal of clinical immunology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcoidosis is a multi-factorial systemic disease of granulomatous inflammation. Current concepts of the aetiology include interactions of unknown environmental triggers with an inherited susceptibility. Toll-like receptors (TLRs) are main components of innate immunity and therefore TLR genes are candidate susceptibility genes in sarcoidosis. Ten members of the human TLR gene family have been identified and mapped to seven chromosomal segments. The aim of this study was to investigate all known TLR gene loci for genetic linkage with sarcoidosis and to follow positive signals with different methods. We analysed linkage of TLR gene loci to sarcoidosis by use of closely flanking microsatellite markers in 83 families with 180 affected siblings. We found significant linkage between sarcoidosis and markers of the TLR4 gene locus on chromosome 9q (non-parametric linkage score 2.63, P = 0.0043). No linkage was found for the remaining TLR gene loci. We subsequently genotyped 1203 sarcoidosis patients from 997 families, 1084 relatives and 537 control subjects for four single nucleotide polymorphisms of TLR4, including Asp299Gly and Thr399Ile. This genotype data set was studied by case-control comparisons and transmission disequilibrium tests, but showed no significant results. In summary, TLR4 - w ith significant genetic linkage results - appears to be the most promising member of the TLR gene family for further investigation in sarcoidosis. However, our results do not confirm the TLR4 polymorphisms Asp299Gly and Thr399Ile as susceptibility markers. Our results rather point to another as yet unidentified variant within or close to TLR4 that might confer susceptibility to sarcoidosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.