Evidence map›Paper›PMID 18422625›Full record

ReviewFEMS microbiology letters2008

Animal models of mucosal Candida infection.

Julian R Naglik, Paul L Fidel, Frank C Odds

Abstract readReview
In one paragraph

Review in FEMS microbiology letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Review
  2. Anatomopathological uterine findings ofJournal of medical microbiology · 2026
    Article
  3. Innovative simvastatin-loaded emulgel effectively treats vulvovaginal candidiasis: in vivo efficacy and in vitro biopharmaceutical analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  4. Comparative analysis of two immunosuppression protocols for vulvovaginal candidiasis induction in Wistar rats.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  5. Candida albicans migrates itself from the vagina to the uterus and ovaries in estrogenized mice.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Chitosan nanoparticles encapsulating farnesol evaluated in vivo against Candida albicans.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  11. Article
  12. Review
  13. Molecular association ofFrontiers in cellular and infection microbiology · 2023
    Review
  14. Activity of Novel Ultrashort Cyclic Lipopeptides against Biofilm ofInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. A Denture Use Model Associated withJournal of fungi (Basel, Switzerland) · 2022
    Article
  18. Review
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julian R NaglikDepartment of Oral Immunology, King's College London Dental Institute, King's College London, London, UK. julian.naglik@kcl.ac.uk
Paul L Fidel
Frank C Odds

Funding

The oral mucosal proteome: perturbation in HIV infection and Candida co infectionR01DE017514 · NIDCR · KING'S COLLEGE LONDON · PI CHALLACOMBE, STEPHEN J · 2006 to 2010
$1.3M
NIDCR NIH HHS R01 DE017514
6 · The paper itself

Abstract

Rodent models of oral, vaginal and gastrointestinal Candida infection are described and discussed in terms of their scientific merits. The common feature of all experimental mucosal Candida infections is the need for some level of host immunocompromise or exogenous treatment to ensure quantitatively reproducible disease. A growing literature describes the contributions of such candidiasis models to our understanding of certain aspects of fungal virulence and host response to mucosal Candida albicans challenge. Evidence to date shows that T-lymphocyte responses dominate host immune defences to oral and gastrointestinal challenge, while other, highly compartmentalized responses defend vaginal surfaces. By contrast the study of C. albicans virulence factors in mucosal infection models has only begun to unravel the complex of attributes required to define the difference between strongly and weakly muco-invasive strains.

Indexed as

Disease Models, AnimalRodentiaAnimalsCandida albicansCandidiasis, OralCandidiasis, VulvovaginalFemaleGastrointestinal DiseasesHost-Pathogen InteractionsIntestinal MucosaT-LymphocytesVirulence FactorsVirulence Factors

Identifiers

PMID18422625
PMCPMC3244615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.