ArticleAmerican journal of human genetics1991
The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester, MN. I. Pleiotropic effects on means and variances.
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Atherosclerosis
Sodium Transport: Genetics and Hypertension
Genetic Epidemiology of Coronary Heart Disease
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis.American journal of Alzheimer's disease and other dementias · 2014Pooled it
- Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory.PloS one · 2013Trial
- A new test for trait mean and variance detects unreported loci for blood-pressure variation.American journal of human genetics · 2024Article
- ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population.Frontiers in aging neuroscience · 2017Article
- Statin users without an APOE-epsilon4 allele have increased insulin resistance.Journal of Alzheimer's disease : JAD · 2010Article
- Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts.Molecular biology reports · 2008Article
- Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study.Genes & nutrition · 2008Article
- Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease.Genetic epidemiology · 2007Article
- Subsets of SNPs define rare genotype classes that predict ischemic heart disease.Human genetics · 2007Article
- Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis.Genes and immunity · 2005Article
- Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism.Human genetics · 2004Article
- A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome research · 2001Article
- Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study.BMC medical genetics · 2001Article
- Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins.American journal of human genetics · 1997Article
- Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.Genetics · 1996Article
- Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men.Human genetics · 1996Article
- Screening for naturally occurring apolipoprotein A-I variants: apo A-I(delta K107) is associated with low HDL-cholesterol levels in men but not in women.Human genetics · 1995Article
- Genetic and environmental sources of fibrinogen variability in Israeli families: the Kibbutzim Family Study.American journal of human genetics · 1995Article
- The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances.American journal of human genetics · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
The influences of the apolipoprotein E (Apo E) polymorphism and of gender on the distributions of plasma levels of total cholesterol (Total-C), 1n triglycerides (1n Trig), HDL cholesterol (HDL-C), and apolipoproteins AI (Apo AI), AII (Apo AII), 1n E (1nApo E), B (Apo B), CII (Apo CII), and 1n CIII (1nApo CIII) were studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Apo E genotypes influenced both phenotypic level and intragenotype phenotypic variability. The mean levels of six of the nine traits were influenced significantly by Apo E genotype. Intragenotype variability in eight of the nine traits was significantly different among Apo E genotypes. These effects were estimated separately in males and females. The contribution of allelic variation in the Apo E gene to the definition of the multivariate mena and variance of the lipid and apolipoprotein hyperspace was evaluated. These findings were used to demonstrate how heterogeneity of risk-factor-trait variance among genotype/gender-specific subgroups of the population at large may influence the evaluation of risk of coronary artery disease.
Indexed as
Identifiers
1842218PMC1686446What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.