ReviewAmino acids2008
Bridging protein local structures and protein functions.
Review in Amino acids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Special Issue "Mechanism of Enzyme Catalysis: When Structure Meets Function".International journal of molecular sciences · 2026Article
- Functional Annotation and Molecular Characterization of a Hypothetical Protein FromEvolutionary bioinformatics online · 2026Article
- Language models can identify enzymatic binding sites in protein sequences.Computational and structural biotechnology journal · 2024Article
- Exploration of Molecular Mechanisms of Immunity in the Pacific Oyster (Animals : an open access journal from MDPI · 2024Article
- An Investigation of the JAZ Family and the CwMYC2-like Protein to Reveal Their Regulation Roles in the MeJA-Induced Biosynthesis of β-Elemene inInternational journal of molecular sciences · 2023Article
- Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis.Genomics & informatics · 2023Article
- Alternative Proteins as a Source of Bioactive Peptides: The Edible Snail and Generation of Hydrolysates Containing Peptides with Bioactive Potential for Use as Functional Foods.Foods (Basel, Switzerland) · 2021Article
- BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities.International journal of molecular sciences · 2019Article
- Structure alignment-based classification of RNA-binding pockets reveals regional RNA recognition motifs on protein surfaces.BMC bioinformatics · 2017Article
- Common Amino Acid Subsequences in a Universal Proteome--Relevance for Food Science.International journal of molecular sciences · 2015Review
- Mining the entire Protein DataBank for frequent spatially cohesive amino acid patterns.BioData mining · 2015Article
- Prediction of hot spots in protein interfaces using extreme learning machines with the information of spatial neighbour residues.IET systems biology · 2014Article
- Analysis and classification of DNA-binding sites in single-stranded and double-stranded DNA-binding proteins using protein information.IET systems biology · 2014Article
- An improved sequence based prediction protocol for DNA-binding proteins using SVM and comprehensive feature analysis.BMC bioinformatics · 2013Article
- A novel method to compare protein structures using local descriptors.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review, we summarize the repertoire of methods currently being applied and report recent progress in the field of in silico annotation of protein function based on the accumulation of vast amounts of sequence and structure data. In particular, we emphasize the newly developed structure-based methods, which are able to identify locally structural motifs and reveal their relationship with protein functions. These methods include computational tools to identify the structural motifs and reveal the strong relationship between these pre-computed local structures and protein functions. We also discuss remaining problems and possible directions for this exciting and challenging area.
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Registered trials
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