ArticleMolecular and cellular biochemistry2008
Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Dysregulation of miRNAs in Sicilian Patients with Autism Spectrum Disorder.Biomedicines · 2026Article
- The Janus face of antipsychotics in glial cells: Focus on glioprotection.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress.International journal of molecular sciences · 2019Article
- Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?Biomolecules · 2018Review
- Human Aquaporin 4 Gene Polymorphisms and Haplotypes Are Associated With Serum S100B Level and Negative Symptoms of Schizophrenia in a Southern Chinese Han Population.Frontiers in psychiatry · 2018Article
- Knowledge-Guided Bioinformatics Model for Identifying Autism Spectrum Disorder Diagnostic MicroRNA Biomarkers.Scientific reports · 2016Article
- AKAPs integrate genetic findings for autism spectrum disorders.Translational psychiatry · 2013Article
- Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.Metabolic brain disease · 2012Article
- A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children.Journal of neuroinflammation · 2012Article
- Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions.European archives of psychiatry and clinical neuroscience · 2010Article
- Induction of S100B secretion in C6 astroglial cells by the major metabolites accumulating in glutaric acidemia type I.Metabolic brain disease · 2010Article
- Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.Prostaglandins & other lipid mediators · 2010Review
- S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance.Cardiovascular psychiatry and neurology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.