ArticleScience (New York, N.Y.)2008
The chemical genomic portrait of yeast: uncovering a phenotype for all genes.
Article in Science (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 569 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
569 citing papers in PubMed.
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- How physiology solves the gene-centric impasse.Experimental physiology · 2026Review
- The cardiac pacemakers: A paradigm of robustness in evolutionary biology.The Journal of physiology · 2026Review
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- Gene loss and compensatory evolution as a source of metabolic preadaptations.Molecular biology and evolution · 2026Article
- Sterol divergence across eukaryotic kingdoms determines membrane susceptibility to saponins, a class of plant defense compounds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The principles of systems biology.Experimental physiology · 2026Review
- Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast.Cells · 2026Article
- Experimental assessment of AI-based interactome mapping.Nature communications · 2026Article
- The impact of rearing environment on C. elegans: phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats.Biology open · 2026Article
- From one genome to thousands, and beyond.FEMS yeast research · 2026Review
- Life beyond 6000 genes: from sequence to synthesis in a post-genomics era.FEMS yeast research · 2026Review
- MGANSL: multi-network representation generating with generative adversarial network for synthetic lethality prediction.BMC bioinformatics · 2025Article
- The impact of rearing environment onbioRxiv : the preprint server for biology · 2025Article
- Barcode sequencing: a robust, platform-agnostic method for massively parallel cell-based screens.G3 (Bethesda, Md.) · 2025Article
- The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast.Disease models & mechanisms · 2025Article
- Peering into the Bacterial Cell: From Transcription to Functional Genomics.Journal of molecular biology · 2025Review
- New lessons from biology for economics and business: a systems approach to non-market environments.Journal of the Royal Society, Interface · 2024Article
509 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed 1144 chemical genomic assays on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growth fitness of each deletion strain in the presence of chemical or environmental stress conditions. We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.