ArticleProceedings of the National Academy of Sciences of the United States of America2008
The MUT9p kinase phosphorylates histone H3 threonine 3 and is necessary for heritable epigenetic silencing in Chlamydomonas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 69 citations in OpenAlex.
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- Proteomic analysis reveals molecular changes following genetic engineering in Chlamydomonas reinhardtii.BMC microbiology · 2024Article
- Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation.Nature communications · 2023Article
- Current Nuclear Engineering Strategies in the Green MicroalgaLife (Basel, Switzerland) · 2023Review
- Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis.Scientific reports · 2022Article
- Concerto on Chromatin: Interplays of Different Epigenetic Mechanisms in Plant Development and Environmental Adaptation.Plants (Basel, Switzerland) · 2021Review
- An Improved Top-Down Mass Spectrometry Characterization ofJournal of the American Society for Mass Spectrometry · 2021Article
- Genome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types.BMC plant biology · 2021Article
- Phosphorylation of Histone H2A at Serine 95 Is Essential for Flowering Time and Development inFrontiers in plant science · 2021Article
- Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity.The Biochemical journal · 2020Review
- Chromatin regulation in plant hormone and plant stress responses.Current opinion in plant biology · 2020Review
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- Sperm DNA Integrity and Male Fertility in Farm Animals: A Review.Frontiers in veterinary science · 2020Review
- Good News for Nuclear Transgene Expression inCells · 2019Review
- Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1.The New phytologist · 2018Article
- MLK1 and MLK2 integrate gibberellins and circadian clock signaling to modulate plant growth.Plant signaling & behavior · 2018Article
- New insights into the mechanisms of phytochrome-cryptochrome coaction.The New phytologist · 2018Review
- MLK1 and MLK2 Coordinate RGA and CCA1 Activity to Regulate Hypocotyl Elongation inThe Plant cell · 2018Article
- Know Your Histone (Zip) Code: Flowering Time and Phosphorylation of Histone H2A on Serine 95.The Plant cell · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in chromatin organization are emerging as key regulators in nearly every aspect of DNA-templated metabolism in eukaryotes. Histones undergo many, largely reversible, posttranslational modifications that affect chromatin structure. Some modifications, such as trimethylation of histone H3 on Lys 4 (H3K4me3), correlate with transcriptional activation, whereas others, such as methylation of histone H3 on Lys 27 (H3K27me), are associated with silent chromatin. Posttranslational histone modifications may also be involved in the inheritance of chromatin states. Histone phosphorylation has been implicated in a variety of cellular processes but, because of the dynamic nature of this modification, its potential role in long-term gene silencing has remained relatively unexplored. We report here that a Chlamydomonas reinhardtii mutant defective in a Ser/Thr protein kinase (MUT9p), which phosphorylates histones H3 and H2A, shows deficiencies in the heritable repression of transgenes and transposons. Moreover, based on chromatin immunoprecipitation analyses, phosphorylated H3T3 (H3T3ph) and monomethylated H3K4 (H3K4me1) are inversely correlated with di/trimethylated H3K4 and associate preferentially with silenced transcription units. Conversely, the loss of those marks in mutant strains correlates with the transcriptional reactivation of transgenes and transposons. Our results suggest that H3T3ph and H3K4me1 function as reinforcing epigenetic marks for the silencing of euchromatic loci in Chlamydomonas.
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