ArticleEndocrinology2008
Prolactin promotes the secretion of active cathepsin D at the basal side of rat mammary acini.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk.BMC veterinary research · 2016Article
- Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon.Biology and medicine (Aligarh) · 2014Article
- N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.PloS one · 2011Article
- Article
- The mammary gland vasculature revisited.Journal of mammary gland biology and neoplasia · 2010Review
- Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer.Cancer biology & therapy · 2010Article
- Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop.Journal of cellular and molecular medicine · 2009Article
- The role of cathepsins in involution and breast cancer.Journal of mammary gland biology and neoplasia · 2009Article
- Differentiation of the mammary epithelial cell during involution: implications for breast cancer.Journal of mammary gland biology and neoplasia · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cathepsin D (CD), a lysosomal aspartic protease present in mammary tissue and milk in various molecular forms, is also found in the incubation medium of mammary acini in molecular forms that are proteolytically active on prolactin at a physiological pH. Because prolactin controls the vesicular traffic in mammary cells, we studied, in vivo and in vitro, its effects on the polarized transport and secretion of various forms of CD in the rat mammary gland. CD accumulated in vesicles not involved in endocytosis in the basal region of cells. Prolactin increased this accumulation and the release of endosomal active single-chain CD at the basal side of acini. The CD-mediated proteolysis of prolactin, leading to the antiangiogenic 16-kDa form, at a physiological pH, was observed only in conditioned medium but not milk. These data support the novel concept that an active molecular form of CD, secreted at the basal side of the mammary epithelium, participates in processing blood-borne prolactin outside the cell, this polarized secretion being controlled by prolactin itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.