ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Postnatal changes in the expression of serotonin 2A receptors in various brain stem nuclei of the rat.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output.Developmental neurobiology · 2022Article
- Orexin contributes to eupnea within a critical period of postnatal development.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex.Physiological reports · 2021Article
- Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity.Respiratory physiology & neurobiology · 2020Review
- The serotonergic system and the control of breathing during development.Respiratory physiology & neurobiology · 2019Review
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- Pituitary adenylate cyclase-activating polypeptide: Postnatal development in multiple brain stem respiratory-related nuclei in the rat.Respiratory physiology & neurobiology · 2019Article
- Brainstem catecholaminergic neurones and breathing control during postnatal development in male and female rats.The Journal of physiology · 2018Article
- Effects of neonatal hyperoxia on the critical period of postnatal development of neurochemical expressions in brain stem respiratory-related nuclei in the rat.Physiological reports · 2018Article
- Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance during the critical period of postnatal respiratory development in the rat.Physiological reports · 2015Article
- Neurotoxicity of prenatal alcohol exposure on medullary pre-Bötzinger complex neurons in neonatal rats.Neural regeneration research · 2015Article
- Reduced levels of brain-derived neurotrophic factor contribute to synaptic imbalance during the critical period of respiratory development in rats.The European journal of neuroscience · 2014Article
- Postnatal development of glycine receptor subunits α1, α2, α3, and β immunoreactivity in multiple brain stem respiratory-related nuclear groups of the rat.Brain research · 2013Article
- Loss of motoneurons in the ventral compartment of the rat hypoglossal nucleus following early postnatal exposure to alcohol.Journal of chemical neuroanatomy · 2013Article
- Gender considerations in ventilatory and metabolic development in rats: special emphasis on the critical period.Respiratory physiology & neurobiology · 2013Article
- Postnatal development of brain-derived neurotrophic factor (BDNF) and tyrosine protein kinase B (TrkB) receptor immunoreactivity in multiple brain stem respiratory-related nuclei of the rat.The Journal of comparative neurology · 2013Article
- Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.Respiratory physiology & neurobiology · 2013Review
- Pontine mechanisms of respiratory control.Comprehensive Physiology · 2012Review
- Postnatal development of Na(+)-K(+)-2Cl(-) co-transporter 1 and K(+)-Cl(-) co-transporter 2 immunoreactivity in multiple brain stem respiratory nuclei of the rat.Neuroscience · 2012Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Previously, we reported a critical period [around postnatal day (P) 12-13 in the rat] in respiratory network development when distinct neurochemical, metabolic, and physiological changes occur. Since serotonin 2A (5-HT(2A)) receptors play an important role in respiratory modulation, we hypothesized that they may undergo developmental adjustments during the critical period. Semi-quantitative immunohistochemical analyses were conducted in labeled neurons in a number of brain stem nuclei with or without known respiratory functions from P2 to P21 in rats. Our data indicate that the expressions of 5-HT(2A) receptors in neurons of the pre-Bötzinger complex, the nucleus ambiguus, and the hypoglossal nucleus were maintained within a relatively narrow range between P2 and P21, with a dip at P3-P4 and a significant reduction only at P12. This change was not observed in the nonrespiratory cuneate nucleus. These results suggest that reduced expressions of 5-HT(2A) receptors at P12 contributes to neurochemical imbalance within brain stem respiratory nuclei at that time and may be involved in decreased hypoxic ventilatory response at this critical period of development.
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