ArticleMolecular and cellular neurosciences2008
Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.
Article in Molecular and cellular neurosciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Evolution and Development of the Inner Ear Efferent System: Transforming a Motor Neuron Population to Connect to the Most Unusual Motor Protein via Ancient Nicotinic Receptors.Frontiers in cellular neuroscience · 2017Review
- Assessment of the expression and role of the α1-nAChR subunit in efferent cholinergic function during the development of the mammalian cochlea.Journal of neurophysiology · 2016Article
- Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse.The Journal of comparative neurology · 2015Article
- Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.PloS one · 2013Article
- Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear.Neuroscience · 2011Article
- Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Oncomodulin identifies different hair cell types in the mammalian inner ear.The Journal of comparative neurology · 2010Article
- Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs.Developmental neurobiology · 2009Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the possibility of a muscle-like mechanism for clustering and assembly of nAChRs in hair cells. We focused our investigations on rapsyn and RIC-3. Rapsyn interacts with the cytoplasmic loop of nAChR alpha9 subunits but not nAChR alpha10 subunits. Although rapsyn and RIC-3 increase nAChR alpha9 expression, rapsyn plays a greater role in receptor clustering while RIC-3 is important for acetylcholine-induced calcium responses. Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.