ArticleThe Journal of infectious diseases2008
Seasonality of antibiotic-resistant streptococcus pneumoniae that causes acute otitis media: a clue for an antibiotic-restriction policy?
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Seasonality of antimicrobial resistance rates in respiratory bacteria: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Korean clinical practice guidelines: otitis media in children.Journal of Korean medical science · 2012Guideline
- Trial
- Epidemiological Markers for Interactions Among Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Upper Respiratory Tract Carriage.The Journal of infectious diseases · 2016Trial
- Prevalence and treatment outcome of cervicitis of unknown etiology.Sexually transmitted diseases · 2013Trial
- Modelling impacts of paediatric amoxicillin shortage management on pneumococcal resistance and invasive disease in Europe.Nature communications · 2026Article
- Durations of Antibiotic Treatment for Acute Otitis Media and Variability in Prescribed Durations Across Two Large Academic Health Systems.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Article
- Antibiotic prescribing practices in community and clinical settings during the COVID-19 pandemic in Nairobi, Kenya.PLOS global public health · 2024Article
- Article
- Frequency of bystander exposure to antibiotics for enteropathogenic bacteria among young children in low-resource settings.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Analysis of multiple bacterial species and antibiotic classes reveals large variation in the association between seasonal antibiotic use and resistance.PLoS biology · 2022Article
- Fate of Macrolide Antibiotics with Different Wastewater Treatment Technologies.Water, air, and soil pollution · 2021Article
- The role of "spillover" in antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Deciphering the Impact of Bystander Selection for Antibiotic Resistance in Neisseria gonorrhoeae.The Journal of infectious diseases · 2020Article
- Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion.eLife · 2019Article
- Evolutionary epidemiology models to predict the dynamics of antibiotic resistance.Evolutionary applications · 2019Article
- Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use.The Journal of infectious diseases · 2019Article
- Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Impact of pneumococcal conjugate vaccines introduction on antibiotic resistance ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundIt is unclear whether reducing antibiotic prescriptions can reduce rates of resistance once resistance becomes prevalent. We attempted to determine whether reduced antibiotic consumption, which is observed yearly in children during the warm season, is associated with a reduction in antibiotic resistance in pneumococcal acute otitis media (AOM).
methodsAntibiotic prescriptions and resistance were measured prospectively during 1999-2003 in 2 demographically distinct populations: Jewish and Bedouin children (aged <5 years) in southern Israel. Associations were assessed using seasonally clustered logistic regression models.
resultsThe study included 236,466 prescriptions and 3609 pneumococcal isolates. Prescription rates decreased during the warm months by 36% and 15% in Jewish and Bedouin children, respectively (P < .001 for the season). Among Jewish children, higher resistance rates were observed during the cold than the warm months (P < .001 for each antibiotic). This difference remained significant after adjustment for age, ethnic group, study year, history of antibiotic use, and serotype. The difference was not observed in Bedouin children.
conclusionsRapid seasonal decline in resistant AOM-causing pneumococci occurred only in Jewish children, among whom a marked prescribing seasonality was noted, and not in Bedouin children, among whom prescription was less seasonal. The rapid seasonal decrease in resistance associated with markedly reduced antibiotic use suggests that drug-resistant pneumococci may pay a fitness cost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.