ArticleJournal of neurotrauma2008
Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.
Article in Journal of neurotrauma, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Targeting androgen receptor stability and degradation: approaches for developing a therapy for spinal and bulbar muscular atrophy.Cell communication and signaling : CCS · 2025Review
- Involvement of histone methylation in the regulation of neuronal death.Journal of physiology and biochemistry · 2023Review
- Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate.Acta biochimica et biophysica Sinica · 2023Article
- The role of ubiquitination in spinal and bulbar muscular atrophy.Frontiers in molecular neuroscience · 2022Review
- Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.Cell death discovery · 2021Article
- miR‑199a decreases Neuritin expression involved in the development of Alzheimer's disease in APP/PS1 mice.International journal of molecular medicine · 2020Article
- The Role of Sex and Sex Hormones in Neurodegenerative Diseases.Endocrine reviews · 2020Review
- Neuroprotective Effects on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons: A Role for Microglia?Developmental neurobiology · 2019Article
- What does the research say about androgen use and cerebrovascular events?Therapeutic advances in drug safety · 2018Review
- Protective effects of gonadal hormones on spinal motoneurons following spinal cord injury.Neural regeneration research · 2018Review
- Protective Effects of Estradiol and Dihydrotestosterone following Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Dihydrotestosterone Treatment Accelerates Autograft Reversal Sciatic Nerve Regeneration in Rats.Neurochemical research · 2018Article
- Neuritin Inhibits Notch Signaling through Interacted with Neuralized to Promote the Neurite Growth.Frontiers in molecular neuroscience · 2017Article
- Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.Frontiers in neuroscience · 2016Article
- Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.Cell reports · 2015Article
- A molecular analysis provides novel insights into androgen receptor signalling in breast cancer.PloS one · 2015Article
- Article
- Drug delivery systems, CNS protection, and the blood brain barrier.BioMed research international · 2014Review
- Axonal localization of neuritin/CPG15 mRNA in neuronal populations through distinct 5' and 3' UTR elements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in the re-establisment of neuronal connectivity following traumatic damage to the central nervous system and that is under the control of several neurotrophic and neuroregenerative factors--and we have hypothesized that neuritin is a mediator of the ability of androgen to increase peripheral nerve regeneration rates in vivo. Testosterone treatment of facial nerve-axotomized hamsters resulted in an approximately 300% increase in neuritin mRNA levels 2 days post-injury. Simultaneous treatment with flutamide, an androgen receptor blocker that is known to prevent androgen enhancement of nerve regeneration, abolished the ability of testosterone to upregulate neuritin mRNA levels. In a corroborative in vitro experiment, the androgen dihydrotestosterone induced an approximately 100% increase in neuritin mRNA levels in motoneuron-neuroblastoma cells transfected with androgen receptors, but not in cells without androgen receptors. These data confirm that neuritin is under the control of androgens, and suggest that neuritin is an important effector of androgen in enhancing peripheral nerve regeneration following injury. Given that neuritin has now been shown to be involved in responses to both central and peripheral injuries, and appears to be a common effector molecule for several neurotrophic and neurotherapeutic agents, understanding the neuritin pathway is an important goal for the clinical management of traumatic nervous system injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.