Trial reportIntensive care medicine2008
Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial.
Trial report in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients.The Cochrane database of systematic reviews · 2015Pooled it
- Efficacy of Noble Metal–alloy Endotracheal Tubes in Ventilator-associated Pneumonia Prevention: a Randomized Clinical TrialBalkan medical journal · 2022Trial
- Silver-Coated Endotracheal Tubes Cleaned With a Mechanism for Secretion Removal.Respiratory care · 2019Trial
- Tolerability and performance of BIP endotracheal tubes with noble metal alloy coating--a randomized clinical evaluation study.BMC anesthesiology · 2015Trial
- Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study).Critical care explorations · 2026Article
- Biofilm Production in Intensive Care Units: Challenges and Implications.Pathogens (Basel, Switzerland) · 2024Review
- Airway and Respiratory Devices in the Prevention of Ventilator-Associated Pneumonia.Medicina (Kaunas, Lithuania) · 2023Review
- Antimicrobial Coating: Tracheal Tube Application.International journal of nanomedicine · 2022Review
- Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.RSC chemical biology · 2021Review
- Avoiding ventilator-associated pneumonia: Curcumin-functionalized endotracheal tube and photodynamic action.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients.Critical care (London, England) · 2019Observational
- Bacteriophage Lysin CF-301, a Potent Antistaphylococcal Biofilm Agent.Antimicrobial agents and chemotherapy · 2017Article
- Anti-biofilm Activity as a Health Issue.Frontiers in microbiology · 2016Review
- Measurement of endotracheal tube secretions volume by micro computed tomography (MicroCT) scan: an experimental and clinical study.BMC anesthesiology · 2014Observational
- Applying insights from biofilm biology to drug development - can a new approach be developed?Nature reviews. Drug discovery · 2013Review
- Use of silver in the prevention and treatment of infections: silver review.Surgical infections · 2013Review
- The influence of lateral and supine position on bacterial colonization of endotracheal tube in neonates admitted to neonatal intensive care unit.Iranian journal of pediatrics · 2012Article
- Technologic advances in endotracheal tubes for prevention of ventilator-associated pneumonia.Chest · 2012Review
- Article
- Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia.Intensive care medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveCoated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization.
designA prospective, randomized clinical trial, phase I-II.
settingAcademic intensive care unit (ICU).
participantsForty-six adult patients expected to need 12-24 h of intubation were randomized into two groups.
interventionsPatients were randomized to be intubated with a standard non-coated ETT (St-ETT, n=23; control group), or with a SSD-coated ETT (SSD-ETT, n=23). MEASUREMENTS AND
resultsCoating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p<0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 microm; in the St-ETT deposits ranged between 50 and 700 microm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p=0.48). No adverse reactions were observed with the implementation of the novel device.
conclusionSSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16 h).
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.