ArticleJournal of neuro-oncology2008
Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Intratumoral and peritumoral post-irradiation changes, but not viable tumor tissue, may respond to bevacizumab in previously irradiated meningiomas.Radiation oncology (London, England) · 2015Trial
- Molecular neuropathology of brain-invasive meningiomas.Brain pathology (Zurich, Switzerland) · 2022Review
- Efficacy of Bevacizumab in High-Grade Meningiomas: A Retrospective Clinical Study.Neuropsychiatric disease and treatment · 2022Article
- Cyclooxygenase Inhibition Alters Proliferative, Migratory, and Invasive Properties of Human Glioblastoma Cells In Vitro.International journal of molecular sciences · 2021Article
- Article
- SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery.Acta neurochirurgica · 2018Article
- CD44 Expression in Meningioma and its Correlation with Proliferation Indices.Journal of clinical and diagnostic research : JCDR · 2017Article
- CD41 and CD45 expression marks the angioformative initiation of neovascularisation in human haemangioblastoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Immunohistochemical characterization of brain-invasive meningiomas.International journal of clinical and experimental pathology · 2014Article
- Proteins involved in regulating bone invasion in skull base meningiomas.Acta neurochirurgica · 2013Article
- Metastasis of lung adenosquamous carcinoma to meningioma: case report with literature review.International journal of clinical and experimental pathology · 2013Review
- Increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 is associated with tumor recurrence of meningioma.International journal of medical sciences · 2013Article
- Fatty acid synthase is a predictive marker for aggressiveness in meningiomas.Journal of neuro-oncology · 2012Article
- MMP-9 expression in meningiomas: a prognostic marker for recurrence risk?Journal of neuro-oncology · 2011Article
- Angiogenesis and expression of estrogen and progesterone receptors as predictive factors for recurrence of meningioma.Journal of neuro-oncology · 2010Article
- Genetic and protein changes of E-cadherin in meningiomas.Journal of cancer research and clinical oncology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most meningiomas are benign tumours of arachnoidal origin, although a small number have high proliferative rates and invasive properties which complicate complete surgical resection and are associated with increased recurrence rates. Few prognostic indicators exist for meningiomas and further research is necessary to identify factors that influence tumour invasion, oedema and recurrence. Paraffin sections from 25 intracranial meningiomas were analysed for expression of the proteins vascular endothelial growth factor (VEGF), VEGF receptors Flt1 and Flk1, E-cadherin, metalloproteinases 2 and 9 (MMP2, MMP9), CD44, receptor for hyaluronic acid-mediated motility (RHAMM), hyaluronic acid (HA), CD45, cyclooxygenase 2 (COX2), brain fatty acid binding protein (BFABP), Ki67, and proliferating cell nuclear antigen (PCNA). Correlations among protein expression were found for several markers of proliferation (Ki67, PCNA, MI) and microvessel density (MVD). COX2 expression increased with increasing with tumour grade and correlated with Ki67, PCNA, MI, MVD, and BFABP. BFABP expression also correlated with Ki67 and PCNA expression. Relationships were also identified among angiogenic factors (VEGF, Flt1, Flk1) and proliferation markers. Oedema was found to correlate with MMP9 expression and MMP9 also correlated with proliferation markers. No correlations were found for MMP2, E-cadherin, or CD44 in meningiomas. In conclusion Ki67, PCNA, MI, MVD, BFABP, and COX2 were significantly correlated with meningioma tumour grade and with each other. These findings, by correlating both intracellular fatty acid transport and eicosanoid metabolism with tumour proliferation, as determined by Ki67 labelling and mitotic index, suggest fatty acids are involved in the progression of meningiomas.
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