SynthesisJournal of human hypertension2008
Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review.
Synthesis in Journal of human hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- ESC Council on hypertension position document on the management of hypertensive emergencies.European heart journal. Cardiovascular pharmacotherapy · 2019Guideline
- Pharmacological interventions for hypertensive emergencies.The Cochrane database of systematic reviews · 2008Pooled it
- Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males.European journal of drug metabolism and pharmacokinetics · 2021Trial
- Characteristics of patients that do not initially respond to intravenous antihypertensives in the emergency department: subanalysis of the CLUE trial.The western journal of emergency medicine · 2015Trial
- Meeting medical emergency response criteria for hypertension is not associated with an increased likelihood of in-hospital mortality in a tertiary referral center.Resuscitation plus · 2024Article
- The Management of Hypertensive Emergencies-Is There a "Magical" Prescription for All?Journal of clinical medicine · 2022Review
- Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- [The hypertensive emergency situation : Recommendations for initial drug therapy management].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Review
- Hypertensive Crisis in Acute Cerebrovascular Diseases Presenting at the Emergency Department: A Narrative Review.Brain sciences · 2021Review
- [Austrian Consensus on High Blood Pressure 2019].Wiener klinische Wochenschrift · 2019Article
- Antihypertensive effect of giant embryo brown rice and pre-germinated giant embryo brown rice on spontaneously hypertensive rats.Food science & nutrition · 2019Article
- To treat or not to treat: that is the question.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Evaluation of the safety and efficacy of metoprolol infusion for children and adolescents with hypertensive crises: a retrospective case series.Pediatric nephrology (Berlin, Germany) · 2017Article
- Treatment of hypertensive emergencies.Annals of translational medicine · 2017Article
- Therapies to Reduce Blood Pressure Acutely.Current hypertension reports · 2016Review
- High-Risk Patients with Hypertension: Clinical Management Options.Clinical medicine reviews in vascular health · 2013Article
- Treatment of hypertension in the inpatient setting: use of intravenous labetalol and hydralazine.Journal of clinical hypertension (Greenwich, Conn.) · 2010Article
- Clinical Practice Guidelines. Management of Hypertension in Tunisian Adults.La Tunisie medicaleArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertensive emergencies occur when high blood pressure is associated with the presence of acute end-organ damage, such as hypertensive encephalopathy. There is controversy as to when and which antihypertensive drugs to use in these situations. Using a comprehensive search strategy in electronic sources, MEDLINE, EMBASE and Cochrane clinical trial register, we conducted a systematic review to look all randomized control trials (RCTs) that compare an antihypertensive drug versus placebo, no treatment or another antihypertensive drug. Fifteen RCTs (representing 869 patients) met the inclusion criteria. Two trials included a placebo arm. All studies (except one) were open-label trials. Seven drug classes were evaluated in those trials: nitrates (nine trials), angiotensin-converting enzyme inhibitors (seven), diuretics (three), calcium channel blockers (six), alpha-1 adrenergic antagonists (four), direct vasodilators (two) and dopamine agonists (one). Mortality event data were reported in seven trials. Due to insufficient data, no meta-analysis was performed for clinical outcomes. Differences in blood pressure changes between antihypertensives were minor. There is no RCT evidence demonstrating that antihypertensive drugs reduce mortality or morbidity in patients with hypertensive emergencies. Furthermore, there is insufficient RCT evidence to determine which drug or drug class is most effective in reducing mortality and morbidity. There were some minor differences in the degree of blood pressure lowering when one class of antihypertensive drug is compared to another. However, the clinical significance is unknown. RCTs are needed to assess different drug classes to determine initial and longer-term mortality and morbidity outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.