ArticleThe EMBO journal2008
Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Substrates, regulation, cellular functions, and disease associations of P4-ATPases.Communications biology · 2025Review
- Article
- SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.Nature communications · 2018Article
- Autophagy in Saccharomyces cerevisiae requires the monomeric GTP-binding proteins, Arl1 and Ypt6.Autophagy · 2016Article
- Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes.Current biology : CB · 2014Article
- Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase.Scientific reports · 2013Article
- Arl1 gets into the membrane remodeling business with a flippase and ArfGEF.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Phospholipid flippases: building asymmetric membranes and transport vesicles.Biochimica et biophysica acta · 2012Review
- Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.Nature cell biology · 2012Article
- The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos.Current biology : CB · 2011Article
- The cellular factors Vps18 and Mon2 are required for efficient production of infectious HIV-1 particles.Journal of virology · 2011Article
- Linking phospholipid flippases to vesicle-mediated protein transport.Biochimica et biophysica acta · 2009Review
- K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Gga proteins represent a family of ubiquitously expressed clathrin adaptors engaged in vesicle budding at the tubular endosomal network/trans Golgi network. Their membrane recruitment is commonly thought to involve interactions with Arf and signals in cargo through the so-called VHS domain. For yeast Gga proteins, however, partners binding to its VHS domain have remained elusive and Gga localization does not absolutely depend on Arf. Here, we demonstrate that yeast Gga recruitment relies on a network of interactions between the scaffold Ysl2p/Mon2p, the small GTPase Arl1p, and the flippase Neo1p. Deletion of either YSL2 or ARL1 causes mislocalization of Gga2p, whereas a neo1-69 mutant accumulates Gga2p on aberrant structures. Remarkably, Ysl2p directly interacts with human and yeast Ggas through the VHS domain, and binding to Gga proteins is also found for the human Ysl2p orthologue hMon2. Thus, Ysl2p represents an essential, evolutionarily conserved member of a network controlling direct binding and membrane docking of Ggas. Because activated Arl1p is part of the network that binds Gga2p, Arf and Arf-like GTPases may interact in a regulatory cascade.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.