ArticleGenome research2008
Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Network medicine: an approach to complex kidney disease phenotypes.Nature reviews. Nephrology · 2023Review
- DGH-GO: dissecting the genetic heterogeneity of complex diseases using gene ontology.BMC bioinformatics · 2023Article
- An Association Study of DNA Methylation and Gene Expression in Angelman Syndrome: A Bioinformatics Approach.International journal of molecular sciences · 2022Article
- A method for estimating coherence of molecular mechanisms in major human disease and traits.BMC bioinformatics · 2020Article
- A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.International journal of molecular sciences · 2017Article
- Ras-like without CAAX 2 (RIT2): a susceptibility gene for autism spectrum disorder.Metabolic brain disease · 2017Article
- Article
- LEAP: biomarker inference through learning and evaluating association patterns.Genetic epidemiology · 2015Article
- Article
- Learning Predictive Interactions Using Information Gain and Bayesian Network Scoring.PloS one · 2015Article
- Integration strategy is a key step in network-based analysis and dramatically affects network topological properties and inferring outcomes.BioMed research international · 2014Article
- Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function.PloS one · 2014Article
- Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA.Genomics · 2013Article
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles.BMC bioinformatics · 2013Article
- Diverse types of genetic variation converge on functional gene networks involved in schizophrenia.Nature neuroscience · 2012Article
- Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors.Biological psychiatry · 2012Article
- Translational bioinformatics: linking the molecular world to the clinical world.Clinical pharmacology and therapeutics · 2012Review
- Mining functional gene modules linked with rheumatoid arthritis using a SNP-SNP network.Genomics, proteomics & bioinformatics · 2012Article
- Mining pure, strict epistatic interactions from high-dimensional datasets: ameliorating the curse of dimensionality.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Common hereditary neurodevelopmental disorders such as autism, bipolar disorder, and schizophrenia are most likely both genetically multifactorial and heterogeneous. Because of these characteristics traditional methods for genetic analysis fail when applied to such diseases. To address the problem we propose a novel probabilistic framework that combines the standard genetic linkage formalism with whole-genome molecular-interaction data to predict pathways or networks of interacting genes that contribute to common heritable disorders. We apply the model to three large genotype-phenotype data sets, identify a small number of significant candidate genes for autism (24), bipolar disorder (21), and schizophrenia (25), and predict a number of gene targets likely to be shared among the disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.