ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Dopamine activates the motor pattern for crawling in the medicinal leech.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 85 citations in OpenAlex.
- Circuit-constrained molecular neuroethology in the medicinal leech Hirudo verbana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
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- Effects of Chronic Exposure to Low Doses of Rotenone on Dopaminergic and Cholinergic Neurons in the CNS ofInternational journal of molecular sciences · 2024Article
- Gut microbiota from patients with Parkinson's disease causes motor deficits in honeybees.Frontiers in microbiology · 2024Article
- Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations.The Journal of experimental biology · 2023Article
- Existence of a Long-Range Caudo-Rostral Sensory Influence in Terrestrial Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in theJournal of neurophysiology · 2022Article
- Intersegmental Interactions Give Rise to a Global Network.Frontiers in neural circuits · 2022Article
- Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Neuromodulatory Selection of Motor Neuron Recruitment Patterns in a Visuomotor Behavior Increases Speed.Current biology : CB · 2020Article
- Phase-Specific Motor Efference during a Rhythmic Motor Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Behavioral analysis of substrate texture preference in a leech, Helobdella austinensis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Article
- Feedback Signal from Motoneurons Influences a Rhythmic Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Spontaneous honeybee behaviour is altered by persistent organic pollutants.Ecotoxicology (London, England) · 2017Article
- Imaging fictive locomotor patterns in larval Drosophila.Journal of neurophysiology · 2015Article
- Compensatory plasticity restores locomotion after chronic removal of descending projections.Journal of neurophysiology · 2015Article
- Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila.Physiological reports · 2015Article
- Multiplexed modulation of behavioral choice.The Journal of experimental biology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Locomotion in segmented animals is thought to be based on the coupling of "unit burst generators," but the biological nature of the unit burst generator has been revealed in only a few animal systems. We determined that dopamine (DA), a universal modulator of motor activity, is sufficient to activate fictive crawling in the medicinal leech, and can exert its actions within the smallest division of the animal's CNS, the segmental ganglion. In the entire isolated nerve cord or in the single ganglion, DA induced slow antiphasic bursting (approximately 15 s period) of motoneurons known to participate in the two-step elongation-contraction cycle underlying crawling behavior. During each cycle, the dorsal (DE-3) and ventral (VE-4) longitudinal excitor motoneurons fired approximately 180 degrees out of phase from the ventrolateral circular excitor motoneuron (CV), which marks the elongation phase. In many isolated whole nerve cords, DE-3 bursting progressed in an anterior to posterior direction with intersegmental phase delays appropriate for crawling. In the single ganglion, the dorsal (DI-1) and ventral (VI-2) inhibitory longitudinal motoneurons fired out of phase with each DE-3 burst, further confirming that the crawl unit burst generator exists in the single ganglion. All isolated ganglia of the CNS were competent to produce DA-induced robust fictive crawling, which typically lasted uninterrupted for 5-15 min. A quantitative analysis indicated that DA-induced crawling was not significantly different from electrically evoked or spontaneous crawling. We conclude that DA is sufficient to activate the full crawl motor program and that the kernel for crawling resides within each segmental ganglion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.