ArticleJournal of virology2008
Bovine papillomavirus type 1: from clathrin to caveolin.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Membrane Rafts: Portals for Viral Entry.Frontiers in microbiology · 2021Review
- Review
- Unraveling the role of membrane microdomains during microbial infections.Cell biology and toxicology · 2017Review
- Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision.The Journal of biological chemistry · 2016Article
- Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes.Cell research · 2015Article
- Coat as a dagger: the use of capsid proteins to perforate membranes during non-enveloped DNA viruses trafficking.Viruses · 2014Review
- Concepts of papillomavirus entry into host cells.Current opinion in virology · 2014Review
- L2, the minor capsid protein of papillomavirus.Virology · 2013Review
- Principles of polyoma- and papillomavirus uncoating.Medical microbiology and immunology · 2012Review
- Host-cell factors involved in papillomavirus entry.Medical microbiology and immunology · 2012Review
- Recent developments in the interactions between caveolin and pathogens.Advances in experimental medicine and biology · 2012Review
- The cytoskeleton in papillomavirus infection.Viruses · 2011Review
- Function of membrane rafts in viral lifecycles and host cellular response.Biochemistry research international · 2011Article
- Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.Molecular cancer therapeutics · 2011Article
- Hijacking the endocytic machinery by microbial pathogens.Protoplasma · 2010Review
- Article
- Current understanding of the mechanism of HPV infection.Gynecologic oncology · 2010Review
- Cellular receptor binding and entry of human papillomavirus.Virology journal · 2010Review
- From touchdown to transcription: the reovirus cell entry pathway.Current topics in microbiology and immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Viruses may infect cells through clathrin-dependent, caveolin-dependent, or clathrin- and caveolin-independent endocytosis. Bovine papillomavirus type 1 (BPV1) entry into cells has been shown to occur by clathrin-dependent endocytosis, a pathway that involves the formation of clathrin-coated pits and fusion to early endosomes. Recently, it has been demonstrated that the closely related JC virus can enter cells in clathrin-coated vesicles and subsequently traffic to caveolae, the organelle where vesicles of the caveolin-dependent pathway deliver their cargo. In this study, we use immunofluorescence staining of BPV1 pseudovirions to show that BPV1 overlaps with the endosome marker EEA1 early during infection and later colocalizes with caveolin-1. We provide evidence through the colocalization of BPV1 with transferrin and cholera toxin B that BPVl trafficking may not be restricted to the clathrin-dependent pathway. Disrupting the entry of caveolar vesicles did not affect BPV1 infection; however, we show that blocking the caveolar pathway postentry results in a loss of BPV1 infection. These data indicate that BPV1 may enter by clathrin-mediated endocytosis and then utilize the caveolar pathway for infection, a pattern of trafficking that may explain the slow kinetics of BPV1 infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.