ArticleJournal of virology2008
Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 71 citations in OpenAlex.
- Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration.PLoS pathogens · 2017Trial
- Peptidoglycan Recognition Protein-S as a Dual-Action Antimicrobial and Immunomodulatory Agent Against Staphylococcus aureus.Probiotics and antimicrobial proteins · 2026Article
- Macrophage-augmented organoids recapitulate the complex pathophysiology of viral diseases and enable development of multitarget therapeutics.Nature biomedical engineering · 2025Article
- Article
- Characterization of Nuclear HIV-Induced Membraneless Organelles Through Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway.Life science alliance · 2022Article
- Review
- Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages.The EMBO journal · 2021Article
- Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.Current HIV research · 2020Article
- Selective use of primate CD4 receptors by HIV-1.PLoS biology · 2019Article
- Article
- HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice.Pathogens (Basel, Switzerland) · 2019Article
- SAMHD1 deficient human monocytes autonomously trigger type I interferon.Molecular immunology · 2018Article
- Review
- Article
- Early cytoplasmic uncoating is associated with infectivity of HIV-1.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages.Virology · 2017Article
- A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection.PLoS pathogens · 2016Article
- The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice.Cell reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood-circulating monocytes migrate in tissues in response to danger stimuli and differentiate there into two major actors of the immune system: macrophages and dendritic cells. Given their migratory behavior and their pivotal role in the orchestration of immune responses, it is not surprising that cells of the monocyte lineage are the target of several viruses, including human immunodeficiency virus type 1 (HIV-1). HIV-1 replicates in monocytoid cells to an extent that is influenced by their differentiation status and modulated by exogenous stimulations. Unstimulated monocytes display a relative resistance to HIV infection mostly exerted during the early steps of the viral life cycle. Despite intensive studies, the identity of the affected step remains controversial, although it is generally assumed to take place after viral entry. We reexamine here the early steps of viral infection of unstimulated monocytes using vesicular stomatitis virus G protein-pseudotyped HIV-1 virions. Our data indicate that a first block to the early steps of infection of monocytes with these particles occurs at the level of viral entry. After entry, reverse transcription and integration proceed with extremely slow kinetics rather than being blocked. Once completed, viral DNA molecules delay entry into the nucleus and integration for up to 5 to 6 days. The inefficacy of these steps accounts for the resistance of monocytes to HIV-1 during the early steps of infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.