ArticleThe Journal of endocrinology2008
Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.
Article in The Journal of endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- AZoological research · 2026Article
- Regulatory interplay of cyclin D1 and INSM1 in suppressing INSL6 expression: Implications for breast cancer biology.Biochemistry and biophysics reports · 2025Article
- Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation.Nature communications · 2025Article
- High expression of insulinoma-associated protein 1 (INSM1) distinguishes colorectal mixed and pure neuroendocrine carcinomas from conventional adenocarcinomas with diffuse expression of synaptophysin.The journal of pathology. Clinical research · 2023Article
- Vitamin D receptor (VDR) contributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming (GHS) rat model.Genes & diseases · 2022Article
- Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.Nature communications · 2020Article
- Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics.Molecular cancer research : MCR · 2019Review
- Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.Nature · 2018Article
- Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction.Cellular signalling · 2014Article
- Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina.Developmental biology · 2013Article
- Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and disease.Cytokine & growth factor reviews · 2013Review
- Fine specificity and cross-reactions of monoclonal antibodies to group B streptococcal capsular polysaccharide type III.Vaccine · 2012Article
- Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation.Journal of cellular physiology · 2012Article
- miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.The EMBO journal · 2011Article
- Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.Endocrinology · 2010Article
- Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factor.PLoS neglected tropical diseases · 2009Article
- INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors.Human gene therapy · 2009Article
- Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Review
- Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, an insulinoma-associated antigen-1 (INSM1)-binding site in the proximal promoter sequence of the insulin gene was identified. The co-transfection of INSM1 with rat insulin I/II promoter-driven reporter genes exhibited a 40-50% inhibitory effect on the reporter activity. Mutational experiments were performed by introducing a substitution, GG to AT, into the INSM1 core binding site of the rat insulin I/II promoters. The mutated insulin promoter exhibited a three- to 20-fold increase in the promoter activity over the wild-type promoter in several insulinoma cell lines. Moreover, INSM1 overexpression exhibited no inhibitory effect on the mutated insulin promoter. Chromatin immunoprecipitation assays using beta TC-1, mouse fetal pancreas, and Ad-INSM1-transduced human islets demonstrated that INSM1 occupies the endogenous insulin promoter sequence containing the INSM1-binding site in vivo. The binding of the INSM1 to the insulin promoter could suppress approximately 50% of insulin message in human islets. The mechanism for transcriptional repression of the insulin gene by INSM1 is mediated through the recruitment of cyclin D1 and histone deacetylase-3 to the insulin promoter. Anti-INSM1 or anti-cyclin D1 morpholino treatment of fetal mouse pancreas enhances the insulin promoter activity. These data strongly support the view that INSM1 is a new zinc-finger transcription factor that modulates insulin gene transcription during early pancreas development.
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