ArticleExperimental neurology2008
Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?
Article in Experimental neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy.NPJ Parkinson's disease · 2023Article
- Preventing Parkinson's Disease: An Environmental Agenda.Journal of Parkinson's disease · 2022Review
- VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20.NPJ Parkinson's disease · 2020Article
- α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo.Redox biology · 2020Article
- Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum.Neuropharmacology · 2020Article
- Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.Acta neuropathologica communications · 2020Article
- A sequential methodology for integral evaluation of motor and non-motor behaviors in parkinsonian rodents.MethodsX · 2020Article
- Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism.Metabolic brain disease · 2019Article
- Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration.Neurobiology of disease · 2019Article
- Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach.Neurochemical research · 2018Article
- Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.Neurobiology of disease · 2018Article
- Biomimetic hydrogels direct spinal progenitor cell differentiation and promote functional recovery after spinal cord injury.Journal of neural engineering · 2018Article
- Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease.Brain structure & function · 2018Article
- Conditioning Against the Pathology of Parkinson's disease.Conditioning medicine · 2018Article
- Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG KScience advances · 2017Article
- Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson's Disease Differently Affects Behavior.Frontiers in behavioral neuroscience · 2017Article
- Article
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5 authors at 2 institutions in 1 country.
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Abstract
In this paper we present two new assays of rat motor behavior which can be used to assess function linked to postural stability in each forelimb independently. Postural instability is a major deficit in Parkinson's disease that is resistant to levodopa therapy and contributes to the risk of falling. We applied both tests, one forelimb at a time, to normal rats as well as rats extensively depleted of dopamine by unilateral infusion of 6-hydroxydopamine (6-OHDA, given in the medial forebrain bundle) to produce a hemi-parkinsonian syndrome. The 6-OHDA rats showed severe postural instability in the impaired forelimb, but unexpectedly showed enhanced function in the non-impaired forelimb. The data suggest that the intact hemisphere may undergo rapid reorganization subsequent to unilateral dopamine depletion, which allows for compensatory function of the "intact" limb. Measurements of amphetamine-induced striatal c-fos expression, as well as behavior results gathered when animals were under the influence of apomorphine or haloperidol, indicate that this potential reorganization may require non-dopaminergic neural plasticity. The relevance of these findings for unilateral rat models of neurological disease is discussed.
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