ArticleBrain research2008
Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.BioMed research international · 2018Article
- Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.Neural plasticity · 2018Article
- Intestinal organoids for assessing nutrient transport, sensing and incretin secretion.Scientific reports · 2015Article
- Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Regulation of adipose differentiation by fructose and GluT5.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Glucose transporter 5 (Glut5) is a high-affinity fructose transporter. It was proposed to be a motor protein or part of the motor complex required for cochlear amplification in outer hair cells (OHCs). Here we show that, in contrast to previous reports, Glut5 is undetectable, and possibly absent, in OHCs harvested from wildtype mice. Further, Glut5-deficient mice display normal OHC morphology and motor function (i.e., nonlinear capacitance and electromotility) and normal cochlear sensitivity and frequency selectivity. We conclude that Glut5 is not required for OHC motility or cochlear amplification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.