ReviewCurrent HIV/AIDS reports2008
New players in cytokine control of HIV infection.
Review in Current HIV/AIDS reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.Journal of genetics · 2018Pooled it
- High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.The Journal of infectious diseases · 2009Trial
- Article
- Article
- The Role of Innate Immunity in Natural Elite Controllers of HIV-1 Infection.Frontiers in immunology · 2022Review
- Association of interleukin-27 gene polymorphisms with susceptibility to HIV infection and disease progression.Journal of cellular and molecular medicine · 2019Article
- The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation.International journal of molecular sciences · 2018Review
- Cytomegalovirus, Macrophages and Breast Cancer.The open virology journal · 2017Review
- Human Th17 Cells Lack HIV-Inhibitory RNases and Are Highly Permissive to Productive HIV Infection.Journal of virology · 2016Article
- Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication.Scientific reports · 2016Article
- Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection.AIDS (London, England) · 2016Article
- The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers.Journal of immunology research · 2016Article
- Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load.Frontiers in immunology · 2013Article
- In vitro restoration of Th17 response during HIV infection with an antiretroviral drug and Th17 differentiation cytokines.AIDS research and human retroviruses · 2012Article
- The Roles and Perspectives of Toll-Like Receptors and CD4(+) Helper T Cell Subsets in Acute Viral Encephalitis.Immune network · 2012Article
- IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- A novel role for Slit2/Robo1 axis in modulating HIV-1 replication in T cells.AIDS (London, England) · 2011Article
- The immunosuppressive role of IL-32 in lymphatic tissue during HIV-1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Article
- Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are involved early in the pathogenesis of HIV infection and disease progression as a component of immunologic dysregulation and immunodeficiency and as determinants controlling virus replication. Several steps, before and after retroviral integration into host DNA in T cells and macrophages, are affected by cytokines whereas CCR5 and CXCR4 binding chemokines can interfere with viral entry. A growing number of potential players--including the gamma-common interleukin (IL)-7, IL-15, and IL-21 together with IL-17, IL-18, IL-19, IL-20, IL-23, and IL-27--are discussed in terms of their perturbation in HIV infection and of their effects on virus replication. Thus, an increasing intersection of HIV infection and the cytokine network represents a crucial determinant of virus replication and immunologic dysregulation and will likely play a key role in the development of effective strategies of HIV prevention and immunologic reconstitution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.