ReviewCurrent cardiology reports2008
Targeting tissue angiotensin-converting enzyme for imaging cardiopulmonary fibrosis.
Review in Current cardiology reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The Impact of COVID-19 on Nuclear Medicine Operations Including Cardiovascular Manifestations in the USA.Seminars in nuclear medicine · 2022Review
- Article
- Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.Respiratory research · 2017Article
- Simvastatin impairs the induction of pulmonary fibrosis caused by a western style diet: a preliminary study.Journal of cellular and molecular medicine · 2015Article
- The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.American journal of respiratory and critical care medicine · 2010Article
- Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart.The Journal of biological chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Convincing clinical and experimental evidence exists that the renin-angiotensin system and its primary effector peptide, angiotensin II, are linked to the pathophysiology of interstitial fibrosis in the heart and in the lung. Tissue angiotensin-converting enzyme and locally synthesized angiotensin II exert local trophic effects, which regulate fibroblast growth and proliferation. Thus, the presence of tissue renin-angiotensin system offers an opportunity for targeted imaging, which may be valuable for understanding the pathobiology of cardiopulmonary disorders and for guiding medical therapy.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.