ArticleAmerican journal of rhinology
Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells.
Article in American journal of rhinology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 116 citations in OpenAlex.
- Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results.The Annals of otology, rhinology, and laryngology · 2023Trial
- Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis.Allergy · 2019Trial
- Article
- Per- and Polyfluoroalkyl Substance-Induced Skin Barrier Disruption and the Potential Role of Calcitriol in Atopic Dermatitis.International journal of molecular sciences · 2025Article
- Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop.International forum of allergy & rhinology · 2025Review
- Human beta defensin-2 protects the epithelial barrier during methicillin-resistantFrontiers in cellular and infection microbiology · 2025Article
- An In Vitro Study Evaluating the Safety of Mesalazine on Human Nasoepithelial Cells.International journal of molecular sciences · 2024Article
- Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium.The Journal of allergy and clinical immunology · 2023Article
- Real-world evidence for the effectiveness and safety of dupilumab in patients with CRSwNP after 1 year of therapy.The World Allergy Organization journal · 2023Article
- Type 2 inflammation in asthma and other airway diseases.ERJ open research · 2022Review
- Impact of type 2 targeting biologics on acute exacerbations of chronic rhinosinusitis.Allergy and asthma proceedings · 2021Article
- Cytokine-Induced Modulation of SARS-CoV2 Receptor Expression in Primary Human Nasal Epithelial Cells.Pathogens (Basel, Switzerland) · 2021Article
- [Antimicrobial peptides and proteins in chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps.Journal of immunology research · 2021Article
- The relationship between allergy and chronic rhinosinusitis.Laryngoscope investigative otolaryngology · 2019Review
- Current Understanding of Nasal Epithelial Cell Mis-Differentiation.Journal of inflammation research · 2019Review
- Severe Obstructive Sleep Apnea Is Associated with Alterations in the Nasal Microbiome and an Increase in Inflammation.American journal of respiratory and critical care medicine · 2019Article
- Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.International forum of allergy & rhinology · 2018Article
- Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Models for the study of nasal and sinus physiology in health and disease: A review of the literature.Laryngoscope investigative otolaryngology · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic rhinosinusitis with nasal polyps (CRSwNPs) is a disorder characterized by persistent eosinophilic Th2 inflammation and frequent sinonasal microbial colonization. It has been postulated that an abnormal mucosal immune response underlies disease pathogenesis. The relationship between Th2 inflammatory cytokines and the innate immune function of sinonasal epithelial cells (SNECs) has not been explored.
methodsHuman SNECs (HSNECs) isolated from control subjects and patients with CRS were assessed for expression of antimicrobial innate immune genes and proinflammatory cytokine genes by real-time polymerase chain reaction, ELISA, and flow cytometry. A model of the Th2 inflammatory environment was created by exposure of primary HSNEC to the Th2 cytokine interleukin (IL)-4 or IL-13 for 36 hours, with subsequent assessment of innate immune gene expression.
resultsHSNEC obtained from CRSwNP patients displayed decreased expression of multiple antimicrobial innate immune markers, including toll-like receptor 9, human beta-defensin 2, and surfactant protein A. Baseline expression of these genes by normal and CRS HSNEC in culture is significantly down-regulated after incubation with IL-4 or IL-13.
conclusionExpression of multiple innate immune genes by HSNEC is reduced in CRSwNP. One mechanism appears to be a direct effect of the leukocyte-derived Th2 cytokines present in the sinonasal mucosa in CRSwNP. Impaired mucosal innate immunity may contribute to microbial colonization and abnormal immune responses associated with CRSwNP.
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