ArticleMolecular pain2008
A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.
Article in Molecular pain, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Suppression of pain-related thoughts and feelings during pain-induction: sex differences in delayed pain responses.Journal of behavioral medicine · 2010Trial
- Association of genetic variation inJournal of pain research · 2018Article
- Impact of the X Chromosome and sex on regulatory variation.Genome research · 2016Article
- Sex- and age-interacting eQTLs in human complex diseases.Human molecular genetics · 2014Article
- Nature and nurture of human pain.Scientifica · 2013Review
- A statistical design for testing transgenerational genomic imprinting in natural human populations.PloS one · 2011Article
- Risk haplotype analysis for bovine paratuberculosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Sex-specific genetic architecture of human disease.Nature reviews. Genetics · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Understanding differences in the genetic architecture of complex traits between the two sexes has significant implications for evolutionary studies and clinical diagnosis. However, our knowledge about sex-specific genetic architecture is limited largely because of a lack of analytical models that can detect and quantify the effects of sex on the complexity of quantitative genetic variation. Here, we derived a statistical model for mapping DNA sequence variants that contribute to sex-specific differences in allele frequencies, linkage disequilibria, and additive and dominance genetic effects due to haplotype diversity. This model allows a genome-wide search for functional haplotypes and the estimation and test of haplotype by sex interactions and sex-specific heritability. The model, validated by simulation studies, was used to detect sex-specific functional haplotypes that encode a pain sensitivity trait in humans. The model could have important implications for mapping complex trait genes and studying the detailed genetic architecture of sex-specific differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.