Evidence map›Paper›PMID 18416567›Full record

ArticleJournal of proteome research2008

Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.

Leesa J Deterding, Maureen K Bunger, Geoffrey C Banks, Kenneth B Tomer, Trevor K Archer

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Chromatin higher-order structures and gene regulation.Current opinion in genetics & development · 2011
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Leesa J DeterdingLaboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, P.O. Box 12233, RTP, North Carolina 27709, USA. deterdi2@niehs.nih.gov
Maureen K Bunger
Geoffrey C Banks
Kenneth B Tomer
Trevor K Archer
National Institute of Environmental Health Sciences · USNational Institutes of Health · US

Funding

Transcriptional Functions of Nuclear Receptors in Cancer CellsZ01ES071006 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ARCHER, TREVOR KEITH · 1999 to 2008
$6.9M
Protein Characterization By Mass SpectrometryZ01ES050171 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TOMER, KENNETH · 2000 to 2008
$1.1M
Intramural NIH HHS Z01 ES050171Intramural NIH HHS Z01 ES071006Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

Global changes in the phosphorylation state of human H1 isoforms isolated from UL3 cells have been investigated using mass spectrometry. Relative changes in H1 phosphorylation between untreated cells and cells treated with dexamethasone or various CDK inhibitors were determined. The specific cyclin-dependent kinase consensus sites of phosphorylation on the histone H1 isoforms that show changes in phosphorylation were also investigated. Three sites of phosphorylation on histone H1.4 isoforms have been identified.

Indexed as

2-AminopurineAmino Acid SequenceAmino Acid SubstitutionAnimalsBlotting, WesternCell Line, TumorCyclin-Dependent KinasesDexamethasoneHistonesHumansMass SpectrometryMiceMolecular Sequence DataPhosphopeptidesPhosphoproteinsPhosphorylation2-AminopurineCVT 313Cyclin-Dependent KinasesDexamethasoneHistonesN(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diaminePhosphopeptidesPhosphoproteinsProtein IsoformsProtein Kinase InhibitorsPurinesSerine Endopeptidasessubmandibular proteinase A

Identifiers

PMID18416567
PMCPMC2761089
OpenAlexW1967510208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.