ArticleWorld journal of gastroenterology2008
Preservation of non-heart-beating donor livers in extracorporeal liver perfusion and histidine-trytophan-ketoglutarate solution.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Porcine Isolated Liver Perfusion for the Study of Ischemia Reperfusion Injury: A Systematic Review.Transplantation · 2018Pooled it
- Donation after cardio-circulatory death liver transplantation.World journal of gastroenterology · 2012Guideline
- Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation.Journal of transplantation · 2012Article
- Current status and recent advances of liver transplantation from donation after cardiac death.World journal of gastrointestinal surgery · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the preservation of non-heart-beating donor (NHBD) livers in cold histidine-trytophan-ketoglutarate (HTK) solution and extracorporeal liver perfusion (ECLP).
methodsLivers harvested from healthy pigs were stored for 10 h in cold HTK solution (group A, n = 4) or perfused with oxygenated autologous blood at body temperature (group B, n = 4). Both groups were then tested on the circuit for 4 h. Bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of extracorporeal livers were tested in each group. Liver tissues from each group were examined at the end of reperfusion.
resultsAt 1, 2, 3 and 4 h after reperfusion, bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of livers in group A were statistically different from those in group B (P < 0.05 or P < 0.01).
conclusionECLP is better than HTK solution to preserve NHBD livers. ECLP can assess the graft viability before liver transplantation.
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Registered trials
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