ArticlePflugers Archiv : European journal of physiology2008
Voltage-activated ion channels and Ca(2+)-induced Ca (2+) release shape Ca (2+) signaling in Merkel cells.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles.Journal of neurophysiology · 2025Article
- Calcium regulation of muscle spindle mechanosensory afferent function.Experimental physiology · 2025Article
- How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.PLoS computational biology · 2023Article
- Intestinal enteroendocrine cells rely on ryanodine and IPThe Journal of physiology · 2023Article
- Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors.IBRO neuroscience reports · 2022Article
- Review
- Voltage-Activated Ion Channels in Non-excitable Cells-A Viewpoint Regarding Their Physiological Justification.Frontiers in physiology · 2018Article
- Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction.Cell reports · 2017Article
- Mechanotransduction in epidermal Merkel cells.Pflugers Archiv : European journal of physiology · 2015Review
- Mechanotransduction in the muscle spindle.Pflugers Archiv : European journal of physiology · 2015Review
- Paraneoplastic cerebellar degeneration associated with noncutaneous Merkel cell carcinoma.Neurology(R) neuroimmunology & neuroinflammation · 2014Article
- Article
- Article
- Sox2 modulates the function of two distinct cell lineages in mouse skin.Developmental biology · 2013Article
- Shear mechanical force induces an increase of intracellular Ca2+ in cultured Merkel cells prepared from rat vibrissal hair follicles.Journal of neurophysiology · 2011Article
- Identification of epidermal progenitors for the Merkel cell lineage.Development (Cambridge, England) · 2010Article
- Rat Merkel cells are mechanoreceptors and osmoreceptors.PloS one · 2009Article
- Article
- Merkel Cells in Somatosensation.Chemosensory perception · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ca(2+) signaling and neurotransmission modulate touch-evoked responses in Merkel cell-neurite complexes. To identify mechanisms governing these processes, we analyzed voltage-activated ion channels and Ca(2+) signaling in purified Merkel cells. Merkel cells in the intact skin were specifically labeled by antibodies against voltage-activated Ca(2+) channels (Ca(V)2.1) and voltage- and Ca(2+)-activated K(+) (BK(Ca)) channels. Voltage-clamp recordings revealed small Ca(2+) currents, which produced Ca(2+) transients that were amplified sevenfold by Ca(2+)-induced Ca(2+) release. Merkel cells' voltage-activated K(+) currents were carried predominantly by BK(Ca) channels with inactivating and non-inactivating components. Thus, Merkel cells, like hair cells, have functionally diverse BK(Ca) channels. Finally, blocking K(+) channels increased response magnitude and dramatically shortened Ca(2+) transients evoked by mechanical stimulation. Together, these results demonstrate that Ca(2+) signaling in Merkel cells is governed by the interplay of plasma membrane Ca(2+) channels, store release and K(+) channels, and they identify specific signaling mechanisms that may control touch sensitivity.
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Registered trials
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