ReviewMolecular neurobiology2008
Locomotor dysfunction and pain: the scylla and charybdis of fiber sprouting after spinal cord injury.
Review in Molecular neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Consequences of Adhesion Molecule Close Homolog of L1 Deficiency for Neurons and Glial Cells in the Mouse Spinal Cord After Injury.Biomolecules · 2025Article
- Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation.Neural regeneration research · 2023Review
- Assessments of sensory plasticity after spinal cord injury across species.Neuroscience letters · 2017Review
- Surgical Neurostimulation for Spinal Cord Injury.Brain sciences · 2017Review
- Taking a bite out of spinal cord injury: do dental stem cells have the teeth for it?Cellular and molecular life sciences : CMLS · 2016Review
- Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury.Brain research · 2015Review
- PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias.Molecular pain · 2015Article
- Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury.Scientific reports · 2015Article
- Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Macrophage migration inhibitory factor (MIF) is essential for inflammatory and neuropathic pain and enhances pain in response to stress.Experimental neurology · 2012Article
- Biodegradable biomatrices and bridging the injured spinal cord: the corticospinal tract as a proof of principle.Cell and tissue research · 2012Review
- The dark side of neuroplasticity.Experimental neurology · 2012Review
- Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury.Neurochemical research · 2011Article
- Mesenchymal stem cells for treatment of CNS injury.Current neuropharmacology · 2010Article
- Translating the frontiers of brain repair to treatments: starting not to break the rules.Neurobiology of disease · 2010Review
- L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury.Experimental neurology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury to the spinal cord (SCI) can produce a constellation of problems including chronic pain, autonomic dysreflexia, and motor dysfunction. Neuroplasticity in the form of fiber sprouting or the lack thereof is an important phenomenon that can contribute to the deleterious effects of SCI. Aberrant sprouting of primary afferent fibers and synaptogenesis within incorrect dorsal horn laminae leads to the development and maintenance of chronic pain as well as autonomic dysreflexia. At the same time, interruption of connections between supraspinal motor control centers and spinal cord output cells, due to lack of successful regenerative sprouting of injured descending fiber tracts, contributes to motor deficits. Similarities in the molecular control of axonal growth of motor and sensory fibers have made the development of cogent therapies difficult. In this study, we discuss recent findings related to the degradation of inhibitory barriers and promotion of sprouting of motor fibers as a strategy for the restoration of motor function and note that this may induce primary afferent fiber sprouting that can contribute to chronic pain. We highlight the importance of careful attentiveness to off-target molecular- and circuit-level modulation of nociceptive processing while moving forward with the development of therapies that will restore motor function after SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.