ReviewMolecular bioSystems2008
The importance of surfaces in single-molecule bioscience.
Review in Molecular bioSystems, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Massively parallel bead-free force spectroscopy with fluorescence.Science advances · 2026Article
- Single-molecule DNA-flow stretching assay as a versatile hybrid tool for investigating DNA-protein interactions.BMB reports · 2025Review
- Advanced surface passivation for high-sensitivity studies of biomolecular condensates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Oriented Soft DNA Curtains for Single-Molecule Imaging.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Improved Glass Surface Passivation for Single-Molecule Nanoarrays.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- An improved surface passivation method for single-molecule studies.Nature methods · 2014Article
- Sample preparation for single virion atomic force microscopy and super-resolution fluorescence imaging.Journal of visualized experiments : JoVE · 2014Article
- Towards physiological complexity with in vitro single-molecule biophysics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- High-throughput single-molecule analysis of DNA-protein interactions by tethered particle motion.Nucleic acids research · 2012Article
- Enhancing single molecule imaging in optofluidics and microfluidics.International journal of molecular sciences · 2011Review
- Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Single-molecule imaging of Bacteroides fragilis AddAB reveals the highly processive translocation of a single motor helicase.Nucleic acids research · 2010Article
- DNA curtains for high-throughput single-molecule optical imaging.Methods in enzymology · 2010Article
- Enzymatic digestion of single DNA molecules anchored on nanogold-modified surfaces.Nanoscale research letters · 2009Article
- Single molecule studies of homologous recombination.Molecular bioSystems · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The last ten years have witnessed an explosion of new techniques that can be used to probe the dynamic behavior of individual biological molecules, leading to discoveries that would not have been possible with more traditional biochemical methods. A common feature among these single-molecule approaches is the need for the biological molecules to be anchored to a solid support surface. This must be done under conditions that minimize nonspecific adsorption without compromising the biological integrity of the sample. In this review we highlight why surface attachments are a critical aspect of many single-molecule studies and we discuss current methods for anchoring biomolecules. Finally, we provide a detailed description of a new method developed by our laboratory for anchoring and organizing hundreds of individual DNA molecules on a surface, allowing "high-throughput" studies of protein-DNA interactions at the single-molecule level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.