ArticlePloS one2008
Functional significance of allelic variation at methuselah, an aging gene in Drosophila.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Effects of aging on gene expression networks in the Drosophila genetic reference panel.Cell reports · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- An antagonistic pleiotropic gene regulates the reproduction and longevity tradeoff.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- G protein-coupled receptors that influence lifespan of human and animal models.Biogerontology · 2022Review
- Genetic Basis of Increased Lifespan and Postponed Senescence inG3 (Bethesda, Md.) · 2020Article
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Review
- Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet inEvolution letters · 2019Article
- Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.Scientific reports · 2018Article
- An inversion supergene in Drosophila underpins latitudinal clines in survival traits.Journal of evolutionary biology · 2018Article
- Horizons in the evolution of aging.BMC biology · 2018Review
- Fitness differences due to allelic variation at Esterase-4 locus in Drosophila ananassae.Journal of genetics · 2017Article
- Effects of aronia extract on lifespan and age-related oxidative stress inFood science and biotechnology · 2017Article
- Article
- Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster.Journal of evolutionary biology · 2016Article
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- Seasonal variation in life history traits in two Drosophila species.Journal of evolutionary biology · 2015Article
- Exploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster.Molecular biology and evolution · 2015Article
- A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.Evolution; international journal of organic evolution · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLongevity and age-specific patterns of mortality are complex traits that vary within and among taxa. Multiple candidate genes for aging have been identified in model systems by extended longevity mutant phenotypes, including the G-protein coupled receptor methuselah (mth) in D. melanogaster. These genes offer important insights into the mechanisms of lifespan determination and have been major targets of interest in the biology of aging. However, it is largely unknown whether these genes contribute to genetic variance for lifespan in natural populations, and consequently contribute to lifespan evolution. METHODOLOGY/PRINCIPLE
findingsFor a gene to contribute to genetic variance for a particular trait, it must meet two criteria: natural allelic variation and functional differences among variants. Previous work showed that mth varies significantly among wild populations; here we assess the functional significance of wild-derived mth alleles on lifespan, fecundity and stress resistance using a quantitative complementation scheme. Our results demonstrate that mth alleles segregating in nature have a functional effect on all three traits. CONCLUSIONS/SIGNIFICANCE: These results suggest that allelic variation at mth contributes to observed differences in lifespan and correlated phenotypes in natural populations, and that evaluation of genetic diversity at candidate genes for aging can be a fruitful approach to identifying loci contributing to lifespan evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.