ArticlePloS one2008
High genetic differentiation between the M and S molecular forms of Anopheles gambiae in Africa.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Transposable element variants and their potential adaptive impact in urban populations of the malaria vectorGenome research · 2022Article
- Unveiling mosquito cryptic species and their reproductive isolation.Insect molecular biology · 2020Review
- Population-specific dynamics and selection patterns of transposable element insertions in European natural populations.Molecular ecology · 2019Article
- Effect of naturally occurringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Population genetics of the Asian tiger mosquito Aedes albopictus, an invasive vector of human diseases.Heredity · 2016Review
- Specific activation of an I-like element in Drosophila interspecific hybrids.Genome biology and evolution · 2014Article
- Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow.Evolutionary applications · 2013Article
- Article
- Article
- tirant, a newly discovered active endogenous retrovirus in Drosophila simulans.Journal of virology · 2012Article
- Gene flow-dependent genomic divergence between Anopheles gambiae M and S forms.Molecular biology and evolution · 2012Article
- Kdr-based insecticide resistance in Anopheles gambiae s.s populations in.BMC research notes · 2011Article
- Insertional variability of four transposable elements and population structure of the midge Chironomus riparius (Diptera).Molecular genetics and genomics : MGG · 2011Article
- Article
- The demographic histories of the M and S molecular forms of Anopheles gambiae s.s.Molecular biology and evolution · 2010Article
- Article
- Authentication scheme for routine verification of genetically similar laboratory colonies: a trial with Anopheles gambiae.BMC biotechnology · 2009Article
- Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.Malaria journal · 2009Article
- Evidence of increasing Leu-Phe knockdown resistance mutation in Anopheles gambiae from Niger following a nationwide long-lasting insecticide-treated nets implementation.Malaria journal · 2008Article
- Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms.Malaria journal · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnopheles gambiae, a major vector of malaria, is widely distributed throughout sub-Saharan Africa. In an attempt to eliminate infective mosquitoes, researchers are trying to develop transgenic strains that are refractory to the Plasmodium parasite. Before any release of transgenic mosquitoes can be envisaged, we need an accurate picture of the differentiation between the two molecular forms of An. gambiae, termed M and S, which are of uncertain taxonomic status. METHODOLOGY/PRINCIPAL
findingsInsertion patterns of three transposable elements (TEs) were determined in populations from Benin, Burkina Faso, Cameroon, Ghana, Ivory Coast, Madagascar, Mali, Mozambique, Niger, and Tanzania, using Transposon Display, a TE-anchored strategy based on Amplified Fragment Length Polymorphism. The results reveal a clear differentiation between the M and S forms, whatever their geographical origin, suggesting an incipient speciation process. CONCLUSIONS/SIGNIFICANCE: Any attempt to control the transmission of malaria by An. gambiae using either conventional or novel technologies must take the M/S genetic differentiation into account. In addition, we localized three TE insertion sites that were present either in every individual or at a high frequency in the M molecular form. These sites were found to be located outside the chromosomal regions that are suspected of involvement in the speciation event between the two forms. This suggests that these chromosomal regions are either larger than previously thought, or there are additional differentiated genomic regions interspersed with undifferentiated regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.