ArticleEnvironmental health perspectives2008
Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 168 citations in OpenAlex.
- Clinical aspects of histological and hormonal parameters in boys with cryptorchidism: Thesis for PhD degree.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Pesticide exposure and related health problems among farmworkers' children: a case-control study in southeast Iran.Environmental science and pollution research international · 2021Article
- Pesticide exposure and the physical and economic health of US crop workers.Applied economic perspectives and policy · 2021Article
- Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides.International journal of environmental research and public health · 2021Review
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Placental transfer of pesticides studied in human placental perfusion.Basic & clinical pharmacology & toxicology · 2020Article
- Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases.Environmental science and pollution research international · 2020Review
- AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool.Bioinformatics (Oxford, England) · 2020Article
- Implementation, mechanisms and effects of maternity protection legislation: a realist narrative review of the literature.International archives of occupational and environmental health · 2018Review
- Association of pesticide exposure with human congenital abnormalities.Toxicology and applied pharmacology · 2018Review
- Human health implications of organic food and organic agriculture: a comprehensive review.Environmental health : a global access science source · 2017Review
- Interaction between prenatal pesticide exposure and a common polymorphism in theClinical epigenetics · 2017Article
- Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.Physiological reviews · 2016Review
- Environmentally Induced Epigenetic Transgenerational Inheritance of Reproductive Disease.Biology of reproduction · 2015Review
- Male reproductive cancers and infertility: a mutual relationship.International journal of molecular sciences · 2015Review
- Possible fetal determinants of male infertility.Nature reviews. Endocrinology · 2014Review
- Environmentally induced epigenetic transgenerational inheritance of male infertility.Current opinion in genetics & development · 2014Review
- Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice.PloS one · 2014Article
- Maternal cypermethrin exposure during the perinatal period impairs testicular development in C57BL male offspring.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants. DESIGN AND MEASUREMENTS: Pregnant women employed in greenhouses in Denmark were consecutively recruited, and 113 mother-son pairs were included. The mothers were categorized as occupationally exposed (91 sons) or unexposed (22 sons) to pesticides during pregnancy. Testicular position and volume, penile length, and position of urethral opening were determined at 3 months of age using standardized techniques. Concentrations of reproductive hormones in serum from the boys were analyzed.
resultsThe prevalence of cryptorchidism at 3 months of age was 6.2% [95% confidence interval (CI), 3.0-12.4]. This prevalence was considerably higher than among Danish boys born in the Copenhagen area (1.9%; 95% CI, 1.2-3.0) examined by the same procedure. Boys of pesticide-exposed mothers showed decreased penile length, testicular volume, serum concentrations of testosterone, and inhibin B. Serum concentrations of sex hormone-binding globulin, follicle-stimulating hormone, and the luteinizing hormone:testosterone ratio were increased compared with boys of nonexposed mothers. For individual parameters, only the decreased penile length was statistically significant (p = 0.04). However, all observed effects were in the anticipated direction, and a joint multivariate test showed that this finding had a p-value of 0.012.
conclusionsOur findings suggest an adverse effect of maternal occupational pesticide exposure on reproductive development in the sons despite current greenhouse safeguards and special measures to protect pregnant women.
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