ArticleEnvironmental health perspectives2008
Personal and ambient air pollution exposures and lung function decrements in children with asthma.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Trial
- TracMyAir: Smartphone-enabled spatiotemporal estimates for inhaled doses of particulate matter and ozone to personalize health outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Observational
- DNA methylation: a potential mediator between air pollution exposures and asthma control.Clinical epigenetics · 2025Article
- Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children.Respiratory research · 2025Article
- eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review.Journal of medical Internet research · 2023Article
- Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis.Journal of asthma and allergy · 2023Article
- The Effects of Short-Term PMInternational journal of environmental research and public health · 2022Article
- An Investigation into Which Methods Best Explain Children's Exposure to Traffic-Related Air Pollution.Toxics · 2022Article
- Air Pollution and Respiratory Hospital Admissions in Kuwait: The Epidemiological Applicability of Predicted PMInternational journal of environmental research and public health · 2022Article
- Impact of acute temperature and air pollution exposures on adult lung function: A panel study of asthmatics.PloS one · 2022Article
- Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PMEnvironmental health : a global access science source · 2021Article
- Fine particulate matter constituents associated with emergency room visits for pediatric asthma: a time-stratified case-crossover study in an urban area.BMC public health · 2021Article
- Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program.Journal of exposure science & environmental epidemiology · 2020Review
- Short-Term Effects of Carbonaceous Components in PMInternational journal of environmental research and public health · 2019Article
- Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.Environment international · 2019Observational
- Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution.Environment international · 2018Article
- Modeling the resiliency of energy-efficient retrofits in low-income multifamily housing.Indoor air · 2018Article
- Developing Multipollutant Exposure Indicators of Traffic Pollution: The Dorm Room Inhalation to Vehicle Emissions (DRIVE) Study.Research report (Health Effects Institute) · 2018Article
- Chemical characterization and quantitativ e assessment of source-specific health risk of trace metals in PMEnvironmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundEpidemiologic studies have shown associations between asthma outcomes and outdoor air pollutants such as nitrogen dioxide and particulate matter mass < 2.5 microm in diameter (PM(2.5)). Independent effects of specific pollutants have been difficult to detect because most studies have relied on highly correlated central-site measurements.
objectivesThis study was designed to evaluate the relationship of daily changes in percent-predicted forced expiratory volume in 1 sec (FEV(1)) with personal and ambient air pollutant exposures.
methodsFor 10 days each, we followed 53 subjects with asthma who were 9-18 years of age and living in the Los Angeles, California, air basin. Subjects self-administered home spirometry in themorning, afternoon, and evening. We measured personal hourly PM(2.5) mass, 24-hr PM(2.5) elemental and organic carbon (EC-OC), and 24-hr NO(2), and the same 24-hr average outdoor central-site(ambient) exposures. We analyzed data with transitional mixed models controlling for personal temperature and humidity, and as-needed beta(2)-agonist inhaler use.
resultsFEV(1) decrements were significantly associated with increasing hourly peak and daily average personal PM(2.5), but not ambient PM(2.5). Personal NO(2) was also inversely associated with FEV(1). Ambient NO(2) was more weakly associated. We found stronger associations among 37 subjects not taking controller bronchodilators as follows: Personal EC-OC was inversely associated with morning FEV(1); for an interquartile increase of 71 microg/m(3) 1-hr maximum personal PM(2.5), overall percent-predicted FEV(1) decreased by 1.32% [95% confidence interval (CI), -2.00 to -0.65%]; and for an interquartile increase of 16.8 ppb 2-day average personal NO(2), overall percent-predicted FEV(1) decreased by 2.45% (95% CI, -3.57 to -1.33%). Associations of both personal PM(2.5) and NO(2) with FEV(1) remained when co-regressed, and both confounded ambient NO(2).
conclusionsIndependent pollutant associations with lung function might be missed using ambient data alone. Different sets of causal components are suggested by independence of FEV(1) associations with personal PM(2.5) mass from associations with personal NO(2).
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