ArticleEnvironmental health perspectives2008
Risk of erectile dysfunction induced by arsenic exposure through well water consumption in Taiwan.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 85 citations in OpenAlex.
- Mitochondrial FIS1 As a Novel Drug Target for the Treatment of Erectile Dysfunction: A Multi-Omic and Epigenomic Association Study.The world journal of men's health · 2025Article
- Article
- Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction.International journal of environmental research and public health · 2021Article
- Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure.Scientific reports · 2021Article
- Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners.International journal of environmental research and public health · 2020Article
- In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City.Environmental health : a global access science source · 2020Article
- Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.Environmental geochemistry and health · 2016Article
- Arsenic Toxicity in Male Reproduction and Development.Development & reproduction · 2015Article
- Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water.Toxicology and applied pharmacology · 2015Article
- Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice.Biomedical and environmental sciences : BES · 2015Article
- Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort.Environmental science & technology · 2014Article
- Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study.Environmental health : a global access science source · 2012Article
- Genetic integrity of the human Y chromosome exposed to groundwater arsenic.BMC medical genomics · 2010Article
- Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.Fertility and sterility · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErectile dysfunction (ED) has a profound impact on the quality of life of many men. Many risk factors are associated with ED, such as aging, sex hormone levels, hypertension, cardiovascular diseases, and diabetes mellitus. Arsenic exposure could damage peripheral vessels and increase the risk of cardiovascular disease. However, the relationship between arsenic exposure and ED has seldom been evaluated.
objectivesIn this study we aimed to investigate whether exposure to arsenic enhances the risk of ED.
methodsWe recruited 177 males >or= 50 years of age through health examinations conducted in three hospitals in Taiwan. We used a questionnaire (International Index of Erectile Function-5) to measure the level of erectile function. Sex hormones, including total testosterone and sex hormone-binding globulin, were determined by radioimmunoassay. We used another standardized questionnaire to collect background and behavioral information (e.g., cigarette smoking; alcohol, tea, or coffee drinking; and physical activity).
resultsThe prevalence of ED was greater in the arsenic-endemic area (83.3%) than in the non-arsenic-endemic area (66.7%). Subjects with arsenic exposure > 50 ppb had a significantly higher risk of developing ED than those with exposure <or= 50 ppb, after adjusting for age, cigarette smoking, diabetes mellitus, hypertension, and cardiovascular disease [odds ratio (OR) = 3.4]. Results also showed that the risk of developing severe ED was drastically enhanced by arsenic exposure (OR = 7.5), after adjusting for free testosterone and traditional risk factors of ED.
conclusionsResults suggested that chronic arsenic exposure has a negative impact on erectile function.
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