ArticleEnvironmental health perspectives2008
Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- 'Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.Environment international · 2022Pooled it
- Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes.Environmental health : a global access science source · 2021Pooled it
- Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood.Environmental epigenetics · 2026Article
- Co-administration of L-Ascorbic Acid and α-Tocopherol Alleviates Arsenic-Induced Immunotoxicities in the Thymus and Spleen by Dwindling Oxidative Stress-Induced Inflammation.Biological trace element research · 2024Article
- Long-term effects of prenatal arsenic exposure from gestational day 9 to birth on lung, heart, and immune outcomes in the C57BL/6 mouse model.Toxicology letters · 2023Article
- Tyrosol and Olive Oil Ameliorate Sodium Arsenate-Induced Nephrotoxicity by Modulating of Oxidative Stress and Histological Changes in Mice.International journal of preventive medicine · 2023Article
- Development and application of an evidence-based directed acyclic graph to evaluate the associations between metal mixtures and cardiometabolic outcomes.Epidemiologic methods · 2023Article
- A pilot study that provides evidence of epigenetic changes among mother-child pairs living proximal to mining in the US.Environmental geochemistry and health · 2022Article
- Review
- Down-regulation of RdRp complex and activated immune response due to increased arsenic level leads to decreased corona virus replication.Current research in microbial sciences · 2022Article
- The Immunotoxicity of Chronic Exposure to High Levels of Lead: An Ex Vivo Investigation.Toxics · 2020Article
- PBMC gene expression profiles of female Bangladeshi adults chronically exposed to arsenic-contaminated drinking water.Environmental pollution (Barking, Essex : 1987) · 2020Article
- Early-Life Arsenic Exposure, Nutritional Status, and Adult Diabetes Risk.Current diabetes reports · 2019Review
- Cross sectional association of arsenic and seroprevalence of hepatitis B infection in the United States (NHANES 2003-2014).Environmental research · 2018Article
- Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.Scientific reports · 2018Article
- Chemical and genetic control of IFNγ-induced MHCII expression.EMBO reports · 2018Article
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
- Effects of Olive Oil supplementation on Sodium Arsenate-induced Hepatotoxicity in Mice.International journal of preventive medicine · 2018Article
- Nevada desert dust with heavy metals suppresses IgM antibody production.Toxicology reports · 2018Article
- The impact of BMI on non-malignant respiratory symptoms and lung function in arsenic exposed adults of Northern Chile.Environmental research · 2017Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundArsenic exposure impairs development and can lead to cancer, cardiovascular disease, and diabetes. The mechanism underlying these effects remains unknown. Primarily because of geologic sources of contamination, drinking-water arsenic levels are above the current recommended maximum contaminant level of 10 microg/L in the northeastern, western, and north central regions of the United States.
objectivesWe investigated the effects of arsenic exposure, defined by internal biomarkers at levels relevant to the United States and similarly exposed populations, on gene expression.
methodsWe conducted separate Affymetrix microarray-based genomewide analyses of expression patterns. Peripheral blood lymphocyte samples from 21 controls interviewed (1999-2002) as part of a case-control study in New Hampshire were selected based on high- versus low-level arsenic exposure levels.
resultsThe biologic functions of the transcripts that showed statistically significant abundance differences between high- and low-arsenic exposure groups included an overrepresentation of genes involved in defense response, immune function, cell growth, apoptosis, regulation of cell cycle, T-cell receptor signaling pathway, and diabetes. Notably, the high-arsenic exposure group exhibited higher levels of several killer cell immunoglobulin-like receptors that inhibit natural killer cell activity.
conclusionsThese findings define biologic changes that occur with chronic arsenic exposure in humans and provide leads and potential targets for understanding and monitoring the pathogenesis of arsenic-induced diseases.
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