ArticleCerebral cortex (New York, N.Y. : 1991)2008
Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons.
Article in Cerebral cortex (New York, N.Y. : 1991), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- MBD3 expression and DNA binding patterns are altered in a rat model of temporal lobe epilepsy.Scientific reports · 2016Article
- A long noncoding RNA associated with susceptibility to celiac disease.Science (New York, N.Y.) · 2016Article
- Physiological functions of MTA family of proteins.Cancer metastasis reviews · 2014Review
- Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections.The Journal of general virology · 2014Article
- Great insight created by tiny holes; celebrating 40 years of brain micropunch technique.Frontiers in neuroanatomy · 2014Article
- Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections.Journal of virology · 2013Article
- Unbiased proteomic analysis of proteins interacting with the HIV-1 5'LTR sequence: role of the transcription factor Meis.Nucleic acids research · 2012Article
- RNA binding proteins accumulate at the postsynaptic density with synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A flexible approach to studying post-transcriptional gene regulation in stably transfected mammalian cells.Molecular biotechnology · 2011Article
- AUF1 is involved in splenic follicular B cell maintenance.BMC immunology · 2010Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Chromatin remodeling plays an important role in coordinating gene expression during cortical development, however the identity of molecular complexes present in differentiating cortical neurons that mediate the process remains poorly understood. The A + U-rich element-binding factor 1 (AUF1) is a known regulator of messenger RNA stability and also acts as a transcription factor upon binding to AT-rich DNA elements. Here we show that AUF1 is specifically expressed in subsets of proliferating neural precursors and differentiating postmitotic neurons of the developing cerebral cortex. Moreover, AUF1 is coexpressed with histone deacetylase 1 (HDAC1) and metastasis-associated protein 2 (MTA2), members of the nucleosome remodeling and histone deacetylase complex. AUF1 specifically and simultaneously binds to HDAC1, MTA2, and AT-rich DNA element, its gene regulatory function is modulated by the extent of histone acetylation and in animals lacking AUF1, the composition of the complex is modified. These results suggest that AUF1 is involved in integrating genetic and epigenetic signals during cortical development through recruiting HDAC1 and MTA2 to AT-rich DNA elements.
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