Evidence map›Paper›PMID 18413248›Full record

ArticleMethods in enzymology2008

In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.

Pedro F Esteban, Paola Caprari, Hye-Young Yoon, Paul A Randazzo, Lino Tessarollo

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pedro F EstebanNeural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland, USA.
Paola Caprari
Hye-Young Yoon
Paul A Randazzo
Lino Tessarollo
National Cancer Institute · USCancer Genetics (United States) · US

Funding

Regulation of ADP-ribosylation factorZIABC007365 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RANDAZZO, PAUL A · 2009 to 2025
$27.9M
Role of Neurotrophins in the Development of the Mammalian Nervous SystemZIABC010390 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TESSAROLLO, LINO · 2009 to 2025
$14.2M
Role of Trk Receptors in the Development and Function of Non-neuronal StructuresZIABC010391 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TESSAROLLO, LINO · 2009 to 2025
$14.0M
REGULATION OF ADP-RIBOSYLATION FACTORZ01BC007365 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RANDAZZO, PAUL A · 1996 to 2008
$3.3M
Role of Neurotrophins in the Development of the Mammalian Nervous SystemZ01BC010390 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TESSAROLLO, LINO · 2000 to 2008
$1.7M
Role of Trk Receptors in the Development and Function of Non-neuronal StructuresZ01BC010391 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TESSAROLLO, LINO · 2000 to 2008
$1.1M
Intramural NIH HHS Z01 BC007365Intramural NIH HHS Z01 BC010390
6 · The paper itself

Abstract

Arf GTP-binding proteins and Rho-family GTPases play key roles in regulating membrane remodeling and cytoskeletal reorganization involved in cell movement. Several studies have implicated neurotrophins and their receptors as upstream activators of these small GTP-binding proteins, however, the mechanisms and the cell type specificity of this neurotrophin activity are still under investigation. Here we describe the rationale and protocols used for the dissection of an NT3 activated pathway that leads to the specific activation of Arf6 and Rac1.

Indexed as

ADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsCell LineEnzyme ActivationHumansMiceMice, Mutant StrainsNeuronsNeurotrophin 3rac1 GTP-Binding ProteinADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanArf6 protein, mouseNeurotrophin 3rac1 GTP-Binding Protein

Identifiers

PMID18413248
PMCPMC10758279
OpenAlexW1573561985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.