Evidence map›Paper›PMID 18413239›Full record

ArticleMethods in enzymology2008

Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.

Sergio D Catz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Rab GTPases implicated in inherited and acquired disorders.Seminars in cell & developmental biology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sergio D CatzDivision of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.
Scripps Research Institute · US

Funding

Vesicular trafficking mechanisms regulating granulocyte functionR01HL088256 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI Sergio Daniel Catz · 2009 to 2026
$9.0M
THE FUNCTION OF NORMAL AND MALIGNANT PHAGOCYTESR01AI024227 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL · 1985 to 2007
$4.0M
FUNCTION OF NORMAL AND MALIGNANT PHAGOCYTESR37AI024227 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI BABIOR, BERNARD M · 1988 to 1997
–
NHLBI NIH HHS R01 HL088256NIAID NIH HHS AI-024227NIAID NIH HHS R01 AI024227
6 · The paper itself

Abstract

Prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are produced by prostate carcinoma cells. Their secretion has implications in both prostate cancer diagnosis and progression. The mechanisms involved in PSA and PSAP secretion in response to androgens have remained relatively unknown. The small GTPase Rab27a regulates exocytosis in several tissues. Here, we present methods for the characterization of Rab27a and its effector JFC1/Slp1 as key components of the secretory machinery that regulates exocytosis in prostate carcinoma cells.

Indexed as

Acid PhosphataseCell Line, TumorDown-RegulationExocytosisHumansMaleMembrane ProteinsPermeabilityProstate-Specific AntigenProstatic NeoplasmsProtein Interaction MappingProtein Structure, TertiaryProtein TransportProtein Tyrosine Phosphatasesrab27 GTP-Binding Proteinsrab GTP-Binding ProteinsAcid PhosphataseMembrane ProteinsProstate-Specific Antigenprostatic acid phosphataseProtein Tyrosine PhosphatasesRAB27A protein, humanrab27 GTP-Binding Proteinsrab GTP-Binding ProteinsRNA, Small InterferingSYTL1 protein, humanSytl1 protein, mouseVesicular Transport Proteins

Identifiers

PMID18413239
PMCPMC11960417
OpenAlexW1527067436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.